Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 718772..719362 Replicon chromosome
Accession NZ_CP064363
Organism Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)


Gene name pemK Uniprot ID A0A741MVU5
Locus tag IUJ39_RS03695 Protein ID WP_000373725.1
Coordinates 719030..719362 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A741N4R3
Locus tag IUJ39_RS03690 Protein ID WP_000288813.1
Coordinates 718772..719029 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ39_RS03680 (717759) 717759..718220 + 462 WP_140197988.1 hypothetical protein -
IUJ39_RS03685 (718217) 718217..718423 + 207 WP_140197989.1 helix-turn-helix transcriptional regulator -
IUJ39_RS03690 (718772) 718772..719029 + 258 WP_000288813.1 hypothetical protein Antitoxin
IUJ39_RS03695 (719030) 719030..719362 + 333 WP_000373725.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IUJ39_RS03700 (720061) 720061..720945 + 885 WP_140197992.1 integrase domain-containing protein -
IUJ39_RS03705 (721659) 721659..721973 + 315 WP_140197993.1 IS66 family insertion sequence element accessory protein TnpB -
IUJ39_RS03710 (721960) 721960..722295 + 336 WP_038395648.1 IS66 family insertion sequence element accessory protein TnpB -
IUJ39_RS03715 (722323) 722323..723894 + 1572 WP_140197994.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11779.61 Da        Isoelectric Point: 10.7239

>T180922 WP_000373725.1 NZ_CP064363:719030-719362 [Salmonella enterica subsp. arizonae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFAVSLDGAGTRTTGVIRCDQPRTI
DMGARNGKRLERLPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T180922 NZ_CP085792:c2879904-2879686 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9332.80 Da        Isoelectric Point: 4.3093

>AT180922 WP_000288813.1 NZ_CP064363:718772-719029 [Salmonella enterica subsp. arizonae]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPRKRPCYSLEELLAQCDPNAEISEEDREWIDAPAV
GREIL

Download         Length: 258 bp

>AT180922 NZ_CP085792:c2880306-2879932 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A741MVU5

Antitoxin

Source ID Structure
AlphaFold DB A0A741N4R3

References