Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 230805..231406 Replicon chromosome
Accession NZ_CP064363
Organism Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)


Gene name doc Uniprot ID A0A741MXD9
Locus tag IUJ39_RS01265 Protein ID WP_000638402.1
Coordinates 231023..231406 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A741MYH8
Locus tag IUJ39_RS01260 Protein ID WP_001195491.1
Coordinates 230805..231026 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ39_RS01230 (226278) 226278..227003 + 726 WP_038395998.1 type III secretion system effector phosphothreonine lyase SpvC -
IUJ39_RS01235 (227256) 227256..227378 + 123 Protein_243 transposase -
IUJ39_RS01240 (227459) 227459..228258 + 800 Protein_244 IS3 family transposase -
IUJ39_RS01245 (228297) 228297..228602 + 306 WP_194840550.1 hypothetical protein -
IUJ39_RS01250 (228617) 228617..229099 + 483 WP_140197924.1 hypothetical protein -
IUJ39_RS01255 (229315) 229315..230076 + 762 WP_079829534.1 Tox-REase-5 domain-containing protein -
IUJ39_RS01260 (230805) 230805..231026 + 222 WP_001195491.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUJ39_RS01265 (231023) 231023..231406 + 384 WP_000638402.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IUJ39_RS01270 (231428) 231428..232435 + 1008 WP_038395995.1 LacI family DNA-binding transcriptional regulator -
IUJ39_RS01275 (232579) 232579..234030 + 1452 WP_038395993.1 Na+/H+ antiporter NhaC -
IUJ39_RS01280 (234043) 234043..235245 + 1203 WP_058819560.1 MalY/PatB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14497.49 Da        Isoelectric Point: 6.9892

>T180913 WP_000638402.1 NZ_CP064363:231023-231406 [Salmonella enterica subsp. arizonae]
MIWVSAQEVIAFHDRILQRFPGVVGLSDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MAFLRRNGIRIHDTDNTLENLTVEAATGEKTVDQLAQYLRKQVDDPL

Download         Length: 384 bp

>T180913 NZ_CP085792:c1301493-1301125 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8176.10 Da        Isoelectric Point: 5.0053

>AT180913 WP_001195491.1 NZ_CP064363:230805-231026 [Salmonella enterica subsp. arizonae]
MQTYTSTQARANISTVLDTALNGEPVEITRRDGSAAVLISKAEFEAWQNAKLDAEFDAIMQRHEHTIRALTDR

Download         Length: 222 bp

>AT180913 NZ_CP085792:c1301711-1301490 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A741MXD9

Antitoxin

Source ID Structure
AlphaFold DB A0A741MYH8

References