Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1722578..1723087 Replicon chromosome
Accession NZ_CP064359
Organism Staphylococcus epidermidis strain PartG-Sepidermidis-RM8376

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag IUJ42_RS08130 Protein ID WP_001829980.1
Coordinates 1722578..1722787 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag IUJ42_RS08135 Protein ID WP_001829893.1
Coordinates 1722794..1723087 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ42_RS08110 (IUJ42_08140) 1718157..1719512 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IUJ42_RS08115 (IUJ42_08145) 1719524..1720597 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
IUJ42_RS08120 (IUJ42_08150) 1720988..1722199 + 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
IUJ42_RS08125 (IUJ42_08155) 1722298..1722435 - 138 WP_001829949.1 Lmo0850 family protein -
IUJ42_RS08130 (IUJ42_08160) 1722578..1722787 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
IUJ42_RS08135 (IUJ42_08165) 1722794..1723087 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
IUJ42_RS08140 (IUJ42_08170) 1723261..1724745 + 1485 WP_002457116.1 cardiolipin synthase -
IUJ42_RS08145 (IUJ42_08175) 1724927..1725580 + 654 WP_001829983.1 HD domain-containing protein -
IUJ42_RS08150 (IUJ42_08180) 1725686..1726558 - 873 WP_002470121.1 membrane protein insertase YidC -
IUJ42_RS08155 (IUJ42_08185) 1726647..1727285 - 639 WP_002505076.1 thiamine phosphate synthase -
IUJ42_RS08160 (IUJ42_08190) 1727291..1728079 - 789 WP_002469583.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T180912 WP_001829980.1 NZ_CP064359:c1722787-1722578 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T180912 NZ_CP085792:c1253074-1252799 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT180912 WP_001829893.1 NZ_CP064359:c1723087-1722794 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT180912 NZ_CP085792:c1253337-1253077 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References