Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1711373..1711902 Replicon chromosome
Accession NZ_CP064359
Organism Staphylococcus epidermidis strain PartG-Sepidermidis-RM8376

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag IUJ42_RS08070 Protein ID WP_001829891.1
Coordinates 1711373..1711735 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag IUJ42_RS08075 Protein ID WP_001829931.1
Coordinates 1711732..1711902 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ42_RS08050 (IUJ42_08080) 1708375..1709145 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
IUJ42_RS08055 (IUJ42_08085) 1709120..1709599 - 480 WP_001829903.1 anti-sigma B factor RsbW -
IUJ42_RS08060 (IUJ42_08090) 1709601..1709927 - 327 WP_001829952.1 anti-sigma factor antagonist -
IUJ42_RS08065 (IUJ42_08095) 1710027..1711028 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
IUJ42_RS08070 (IUJ42_08100) 1711373..1711735 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IUJ42_RS08075 (IUJ42_08105) 1711732..1711902 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IUJ42_RS08080 (IUJ42_08110) 1711989..1713137 - 1149 WP_002457107.1 alanine racemase -
IUJ42_RS08085 (IUJ42_08115) 1713204..1713557 - 354 WP_002457108.1 holo-ACP synthase -
IUJ42_RS08090 (IUJ42_08120) 1713605..1714114 - 510 WP_002457109.1 PH domain-containing protein -
IUJ42_RS08095 (IUJ42_08125) 1714101..1715606 - 1506 WP_002457110.1 PH domain-containing protein -
IUJ42_RS08100 (IUJ42_08130) 1715599..1716078 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T180911 WP_001829891.1 NZ_CP064359:c1711735-1711373 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T180911 NZ_CP085792:c786744-786331 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT180911 WP_001829931.1 NZ_CP064359:c1711902-1711732 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT180911 NZ_CP085792:c786991-786725 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References