Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 560424..560894 Replicon chromosome
Accession NZ_CP064359
Organism Staphylococcus epidermidis strain PartG-Sepidermidis-RM8376

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag IUJ42_RS02610 Protein ID WP_001829569.1
Coordinates 560424..560612 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag IUJ42_RS02615 Protein ID WP_002438963.1
Coordinates 560637..560894 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ42_RS02580 (IUJ42_02635) 556904..557104 + 201 WP_001829681.1 cold-shock protein -
IUJ42_RS02585 (IUJ42_02640) 557725..557949 - 225 WP_001829613.1 hypothetical protein -
IUJ42_RS02590 (IUJ42_02645) 557973..558257 - 285 WP_001829635.1 hypothetical protein -
IUJ42_RS02595 (IUJ42_02650) 558356..559102 - 747 WP_001829580.1 poly-gamma-glutamate hydrolase family protein -
IUJ42_RS02600 (IUJ42_02655) 559387..559620 + 234 WP_001829664.1 hypothetical protein -
IUJ42_RS02605 (IUJ42_02660) 559680..560234 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
IUJ42_RS02610 (IUJ42_02665) 560424..560612 - 189 WP_001829569.1 hypothetical protein Toxin
IUJ42_RS02615 560637..560894 - 258 WP_002438963.1 hypothetical protein Antitoxin
IUJ42_RS02620 (IUJ42_02670) 561303..561506 + 204 WP_001829671.1 sterile alpha motif-like domain-containing protein -
IUJ42_RS02625 (IUJ42_02675) 561498..561734 - 237 WP_002457224.1 hypothetical protein -
IUJ42_RS02630 (IUJ42_02680) 561948..562535 + 588 WP_001829615.1 histidine phosphatase family protein -
IUJ42_RS02635 (IUJ42_02685) 562806..563306 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
IUJ42_RS02640 563693..563880 + 188 Protein_525 hypothetical protein -
IUJ42_RS02645 (IUJ42_02690) 563892..564047 + 156 WP_001829648.1 hypothetical protein -
IUJ42_RS02650 (IUJ42_02695) 564231..564653 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
IUJ42_RS02655 (IUJ42_02700) 564814..565530 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 556904..569922 13018
- flank IS/Tn - - 563892..564047 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(14-90)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T180909 WP_001829569.1 NZ_CP064359:c560612-560424 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T180909 NZ_CP085792:622971-623498 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT180909 WP_002438963.1 NZ_CP064359:c560894-560637 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT180909 NZ_CP085792:622684-622974 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References