Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4932460..4933117 Replicon chromosome
Accession NZ_CP064352
Organism Klebsiella pneumoniae subsp. pneumoniae ATCC 43816

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IT767_RS23690 Protein ID WP_002916310.1
Coordinates 4932707..4933117 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IT767_RS23685 Protein ID WP_002916312.1
Coordinates 4932460..4932726 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT767_RS23660 4927616..4929049 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IT767_RS23665 4929168..4929896 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IT767_RS23670 4929946..4930257 + 312 WP_038432738.1 N(4)-acetylcytidine aminohydrolase -
IT767_RS23675 4930421..4931080 + 660 WP_002916317.1 hemolysin III family protein -
IT767_RS23680 4931231..4932214 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IT767_RS23685 4932460..4932726 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IT767_RS23690 4932707..4933117 + 411 WP_002916310.1 protein YgfX Toxin
IT767_RS23695 4933124..4933645 - 522 WP_004144730.1 flavodoxin FldB -
IT767_RS23700 4933746..4934642 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IT767_RS23705 4934665..4935378 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IT767_RS23710 4935384..4937117 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T180900 WP_002916310.1 NZ_CP064352:4932707-4933117 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T180900 NZ_CP085780:c4644478-4644107 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT180900 WP_002916312.1 NZ_CP064352:4932460-4932726 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180900 NZ_CP085780:c4644723-4644481 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References