Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3727668..3729349 Replicon chromosome
Accession NZ_CP064352
Organism Klebsiella pneumoniae subsp. pneumoniae ATCC 43816

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag IT767_RS17870 Protein ID WP_038432297.1
Coordinates 3727668..3728585 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag IT767_RS17875 Protein ID WP_038432298.1
Coordinates 3728591..3729349 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT767_RS17850 3722974..3724494 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
IT767_RS17855 3724491..3725489 + 999 WP_002885172.1 ribose ABC transporter permease -
IT767_RS17860 3725520..3726461 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
IT767_RS17865 3726536..3727543 + 1008 WP_004186546.1 carbohydrate kinase family protein -
IT767_RS17870 3727668..3728585 - 918 WP_038432297.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IT767_RS17875 3728591..3729349 - 759 WP_038432298.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
IT767_RS17880 3729434..3730162 - 729 WP_038432301.1 response regulator transcription factor -
IT767_RS17885 3730435..3732582 + 2148 WP_077598951.1 formate dehydrogenase subunit alpha -
IT767_RS17890 3732579..3732722 - 144 WP_022631365.1 hypothetical protein -
IT767_RS17895 3733160..3733846 + 687 WP_032421940.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34716.19 Da        Isoelectric Point: 5.4707

>T180896 WP_038432297.1 NZ_CP064352:c3728585-3727668 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAELFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T180896 NZ_CP085780:c2351030-2350545 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAACGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28665.07 Da        Isoelectric Point: 10.1988

>AT180896 WP_038432298.1 NZ_CP064352:c3729349-3728591 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVLLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT180896 NZ_CP085780:c2351284-2351018 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References