Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 4125..5262 Replicon plasmid unnamed1
Accession NZ_CP064344
Organism Enterococcus faecium strain VRE3363

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag IU206_RS13495 Protein ID WP_002401483.1
Coordinates 4125..4988 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag IU206_RS13500 Protein ID WP_000301765.1
Coordinates 4990..5262 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IU206_RS13465 6..1496 - 1491 WP_002380753.1 primase C-terminal domain-containing protein -
IU206_RS13470 1891..2130 - 240 WP_002380754.1 helix-turn-helix domain-containing protein -
IU206_RS13475 2374..2547 - 174 WP_171902975.1 rRNA adenine methyltransferase -
IU206_RS13480 2492..3229 - 738 WP_194967082.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
IU206_RS13485 3354..3449 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
IU206_RS13490 3498..3581 - 84 Protein_5 peptide-binding protein -
IU206_RS13495 4125..4988 - 864 WP_002401483.1 zeta toxin family protein Toxin
IU206_RS13500 4990..5262 - 273 WP_000301765.1 antitoxin Antitoxin
IU206_RS13505 5279..5488 - 210 WP_000527317.1 peptide-binding protein -
IU206_RS13510 5565..6461 - 897 WP_118215883.1 ParA family protein -
IU206_RS13515 6564..8708 - 2145 WP_130006275.1 type IA DNA topoisomerase -
IU206_RS13520 9029..9244 - 216 WP_076720021.1 helix-turn-helix domain containing protein -
IU206_RS13525 9222..9815 - 594 WP_171970647.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) - 1..196063 196063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T180862 WP_002401483.1 NZ_CP064344:c4988-4125 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T180862 NZ_CP085763:c29599-29312 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT180862 WP_000301765.1 NZ_CP064344:c5262-4990 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT180862 NZ_CP085763:c29838-29599 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References