Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2525893..2526504 Replicon chromosome
Accession NZ_CP064334
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-8

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag IUD20_RS11270 Protein ID WP_011098375.1
Coordinates 2526205..2526504 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag IUD20_RS11265 Protein ID WP_004085003.1
Coordinates 2525893..2526201 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD20_RS11235 2522463..2523224 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
IUD20_RS11260 2524416..2525819 + 1404 WP_011098374.1 hypothetical protein -
IUD20_RS11265 2525893..2526201 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
IUD20_RS11270 2526205..2526504 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD20_RS11275 2526592..2527137 + 546 WP_011098376.1 hypothetical protein -
IUD20_RS11280 2527149..2527292 + 144 WP_155115087.1 hypothetical protein -
IUD20_RS11285 2527445..2527825 - 381 WP_004089371.1 DUF596 domain-containing protein -
IUD20_RS11290 2527830..2528960 - 1131 WP_012382788.1 DUF769 domain-containing protein -
IUD20_RS11295 2529268..2529648 - 381 WP_004087391.1 DUF596 domain-containing protein -
IUD20_RS11300 2529660..2531234 - 1575 Protein_2200 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2476652..2532770 56118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T180859 WP_011098375.1 NZ_CP064334:c2526504-2526205 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T180859 NZ_CP085757:c3185615-3185328 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT180859 WP_004085003.1 NZ_CP064334:c2526201-2525893 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT180859 NZ_CP085757:c3185924-3185622 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References