Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1597722..1598308 Replicon chromosome
Accession NZ_CP064334
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-8

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag IUD20_RS07280 Protein ID WP_004089517.1
Coordinates 1598054..1598308 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag IUD20_RS07275 Protein ID WP_004085025.1
Coordinates 1597722..1598057 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD20_RS07245 1593321..1594175 - 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -
IUD20_RS07250 1594667..1595440 + 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
IUD20_RS07255 1595437..1595901 + 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
IUD20_RS07260 1595888..1596601 - 714 WP_011098057.1 site-specific DNA-methyltransferase -
IUD20_RS07265 1596952..1597233 + 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUD20_RS07270 1597243..1597542 + 300 WP_004089519.1 HigA family addiction module antidote protein -
IUD20_RS07275 1597722..1598057 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IUD20_RS07280 1598054..1598308 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
IUD20_RS07285 1598361..1599059 - 699 WP_011098059.1 hypothetical protein -
IUD20_RS07290 1599188..1599649 - 462 WP_011098060.1 hypothetical protein -
IUD20_RS07295 1599646..1600410 - 765 WP_004090689.1 hypothetical protein -
IUD20_RS07300 1600316..1601422 - 1107 WP_012382665.1 YdaU family protein -
IUD20_RS07305 1601419..1601718 - 300 WP_080513037.1 hypothetical protein -
IUD20_RS07310 1601717..1602194 + 478 Protein_1423 conjugal transfer protein -
IUD20_RS07315 1602200..1602805 + 606 WP_004091108.1 conjugal transfer protein TrbN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T180858 WP_004089517.1 NZ_CP064334:c1598308-1598054 [Xylella fastidiosa subsp. fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T180858 NZ_CP085757:c2973251-2972931 [Enterobacter hormaechei]
ATGAATATTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGCAAATGTTACTGGC
AAGCCTGCTAGACCAGCACTATGGCCTCACGCTAAACGACACGCCGTTTAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCCGATGCCGTAAATTTTCTGGTTGAACGCTATGAACTAGTTCGTATTGACCAAAAAGGCTAC
TCTGTGCAAGATCAGGAACCTTGGTTAACTTATATGGATGTCCACCGAGCACAACTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT180858 WP_004085025.1 NZ_CP064334:c1598057-1597722 [Xylella fastidiosa subsp. fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT180858 NZ_CP085757:c2973598-2973272 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGGCTAAAAAGCGATATTGTTCCACGGTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTGCATTTTCTGGCTGACAGGGCTAGTTTGATGGGCAATTTTAGCGATACGGAATGCTTCAAATTGAATGACG
CATTTCCACACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAACTGATCCCCTGTCACCATCGCTGTGTCACT
CTCTACCATAACGGTTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCGGTTTACTCAACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References