180857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1408680..1409157 Replicon chromosome
Accession NZ_CP064334
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-8

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag IUD20_RS06430 Protein ID WP_011097988.1
Coordinates 1408891..1409157 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7G7TPD2
Locus tag IUD20_RS06425 Protein ID WP_004091377.1
Coordinates 1408680..1408907 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD20_RS06385 1403807..1404952 - 1146 WP_011097984.1 baseplate J/gp47 family protein -
IUD20_RS06390 1405051..1405347 + 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUD20_RS06395 1405351..1405656 + 306 WP_004089254.1 putative addiction module antidote protein -
IUD20_RS06400 1405667..1406020 - 354 WP_011097986.1 hypothetical protein -
IUD20_RS06405 1406017..1406658 - 642 WP_004090764.1 hypothetical protein -
IUD20_RS06410 1406655..1407485 - 831 WP_004090766.1 hypothetical protein -
IUD20_RS06415 1407482..1407799 - 318 WP_011097873.1 hypothetical protein -
IUD20_RS06420 1407799..1408569 - 771 WP_004090769.1 hypothetical protein -
IUD20_RS06425 1408680..1408907 + 228 WP_004091377.1 hypothetical protein Antitoxin
IUD20_RS06430 1408891..1409157 + 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD20_RS06435 1409168..1411057 - 1890 WP_011097989.1 hypothetical protein -
IUD20_RS06440 1411014..1411178 - 165 WP_014607750.1 hypothetical protein -
IUD20_RS06445 1411205..1411627 - 423 WP_004085005.1 hypothetical protein -
IUD20_RS06450 1411624..1412061 - 438 WP_011097990.1 DUF3277 family protein -
IUD20_RS06455 1412071..1412292 - 222 Protein_1254 DUF3383 family protein -
IUD20_RS06460 1412321..1413526 - 1206 Protein_1255 transposase -
IUD20_RS06465 1413520..1414125 - 606 Protein_1256 IS607 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1402002..1444916 42914
- flank IS/Tn - - 1413520..1413741 221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T180857 WP_011097988.1 NZ_CP064334:1408891-1409157 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T180857 NZ_CP085757:c1986037-1985627 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8615.63 Da        Isoelectric Point: 5.0958

>AT180857 WP_004091377.1 NZ_CP064334:1408680-1408907 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT180857 NZ_CP085757:c1986284-1986018 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7TPD2

References