Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1323768..1324299 Replicon chromosome
Accession NZ_CP064334
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-8

Toxin (Protein)


Gene name relE Uniprot ID Q87CH1
Locus tag IUD20_RS05955 Protein ID WP_004090909.1
Coordinates 1324018..1324299 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q87CH2
Locus tag IUD20_RS05950 Protein ID WP_004090907.1
Coordinates 1323768..1324031 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD20_RS05925 1318995..1320173 - 1179 WP_011097931.1 phage tail sheath family protein -
IUD20_RS05930 1320238..1321830 - 1593 WP_012382617.1 tail fiber domain-containing protein -
IUD20_RS05935 1321838..1322395 - 558 WP_011097610.1 phage tail protein I -
IUD20_RS05940 1322388..1323280 - 893 Protein_1151 baseplate J/gp47 family protein -
IUD20_RS05945 1323280..1323618 - 339 WP_004090694.1 GPW/gp25 family protein -
IUD20_RS05950 1323768..1324031 + 264 WP_004090907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IUD20_RS05955 1324018..1324299 + 282 WP_004090909.1 type II toxin-antitoxin system YafQ family toxin Toxin
IUD20_RS05960 1324336..1324923 - 588 WP_011097612.1 phage baseplate assembly protein V -
IUD20_RS05965 1324920..1325462 - 543 WP_011097613.1 hypothetical protein -
IUD20_RS05970 1325438..1325959 - 522 WP_011097614.1 hypothetical protein -
IUD20_RS05975 1325956..1326279 - 324 WP_012382618.1 hypothetical protein -
IUD20_RS05980 1326279..1326539 - 261 WP_012382619.1 hypothetical protein -
IUD20_RS05985 1326557..1328431 - 1875 WP_012382620.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1310356..1357075 46719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10936.37 Da        Isoelectric Point: 7.2205

>T180855 WP_004090909.1 NZ_CP064334:1324018-1324299 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Download         Length: 282 bp

>T180855 NZ_CP085757:c943952-943849 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9495.95 Da        Isoelectric Point: 5.6033

>AT180855 WP_004090907.1 NZ_CP064334:1323768-1324031 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Download         Length: 264 bp

>AT180855 NZ_CP085757:943846-944045 [Enterobacter hormaechei]
GATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGTCT
GAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87CH1

Antitoxin

Source ID Structure
AlphaFold DB Q87CH2

References