Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2526504..2527115 Replicon chromosome
Accession NZ_CP064332
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-11

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag IUD21_RS11265 Protein ID WP_011098375.1
Coordinates 2526816..2527115 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag IUD21_RS11260 Protein ID WP_004085003.1
Coordinates 2526504..2526812 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD21_RS11230 2523074..2523835 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
IUD21_RS11255 2525027..2526430 + 1404 WP_011098374.1 hypothetical protein -
IUD21_RS11260 2526504..2526812 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
IUD21_RS11265 2526816..2527115 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD21_RS11270 2527203..2527748 + 546 WP_011098376.1 hypothetical protein -
IUD21_RS11275 2527760..2527903 + 144 WP_155115087.1 hypothetical protein -
IUD21_RS11280 2528056..2528436 - 381 WP_004089371.1 DUF596 domain-containing protein -
IUD21_RS11285 2528441..2529571 - 1131 WP_012382788.1 DUF769 domain-containing protein -
IUD21_RS11290 2529879..2530259 - 381 WP_004087391.1 DUF596 domain-containing protein -
IUD21_RS11295 2530271..2531845 - 1575 Protein_2199 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2477279..2533381 56102


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T180850 WP_011098375.1 NZ_CP064332:c2527115-2526816 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T180850 NZ_CP085753:c4860168-4860065 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT180850 WP_004085003.1 NZ_CP064332:c2526812-2526504 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT180850 NZ_CP085753:4860052-4860261 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAGCCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References