Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1598297..1598883 Replicon chromosome
Accession NZ_CP064332
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-11

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag IUD21_RS07295 Protein ID WP_004089517.1
Coordinates 1598629..1598883 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag IUD21_RS07290 Protein ID WP_004085025.1
Coordinates 1598297..1598632 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD21_RS07260 1593896..1594750 - 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -
IUD21_RS07265 1595242..1596015 + 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
IUD21_RS07270 1596012..1596476 + 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
IUD21_RS07275 1596463..1597176 - 714 WP_011098057.1 site-specific DNA-methyltransferase -
IUD21_RS07280 1597527..1597808 + 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUD21_RS07285 1597818..1598117 + 300 WP_004089519.1 HigA family addiction module antidote protein -
IUD21_RS07290 1598297..1598632 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IUD21_RS07295 1598629..1598883 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
IUD21_RS07300 1598936..1599634 - 699 WP_011098059.1 hypothetical protein -
IUD21_RS07305 1599763..1600224 - 462 WP_011098060.1 hypothetical protein -
IUD21_RS07310 1600221..1600985 - 765 WP_004090689.1 hypothetical protein -
IUD21_RS07315 1600891..1601997 - 1107 WP_012382665.1 YdaU family protein -
IUD21_RS07320 1601994..1602293 - 300 WP_080513037.1 hypothetical protein -
IUD21_RS07325 1602292..1602769 + 478 Protein_1426 conjugal transfer protein -
IUD21_RS07330 1602775..1603380 + 606 WP_004091108.1 conjugal transfer protein TrbN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T180849 WP_004089517.1 NZ_CP064332:c1598883-1598629 [Xylella fastidiosa subsp. fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T180849 NZ_CP085753:c4489326-4488841 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGGAGCGTTAACCATACGCAAGCGACGGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCTCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT180849 WP_004085025.1 NZ_CP064332:c1598632-1598297 [Xylella fastidiosa subsp. fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT180849 NZ_CP085753:c4489580-4489314 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References