180848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1409270..1409747 Replicon chromosome
Accession NZ_CP064332
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-11

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag IUD21_RS06435 Protein ID WP_011097988.1
Coordinates 1409481..1409747 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7G7TPD2
Locus tag IUD21_RS06430 Protein ID WP_004091377.1
Coordinates 1409270..1409497 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD21_RS06390 1404397..1405542 - 1146 WP_011097984.1 baseplate J/gp47 family protein -
IUD21_RS06395 1405641..1405937 + 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUD21_RS06400 1405941..1406246 + 306 WP_004089254.1 putative addiction module antidote protein -
IUD21_RS06405 1406257..1406610 - 354 WP_011097986.1 hypothetical protein -
IUD21_RS06410 1406607..1407248 - 642 WP_004090764.1 hypothetical protein -
IUD21_RS06415 1407245..1408075 - 831 WP_004090766.1 hypothetical protein -
IUD21_RS06420 1408072..1408389 - 318 WP_011097873.1 hypothetical protein -
IUD21_RS06425 1408389..1409159 - 771 WP_004090769.1 hypothetical protein -
IUD21_RS06430 1409270..1409497 + 228 WP_004091377.1 hypothetical protein Antitoxin
IUD21_RS06435 1409481..1409747 + 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD21_RS06440 1409758..1411647 - 1890 WP_011097989.1 hypothetical protein -
IUD21_RS06445 1411604..1411768 - 165 WP_014607750.1 hypothetical protein -
IUD21_RS06450 1411795..1412217 - 423 WP_004085005.1 hypothetical protein -
IUD21_RS06455 1412214..1412651 - 438 WP_011097990.1 DUF3277 family protein -
IUD21_RS06460 1412661..1412882 - 222 Protein_1255 DUF3383 family protein -
IUD21_RS06465 1412911..1414116 - 1206 Protein_1256 transposase -
IUD21_RS06470 1414110..1414715 - 606 Protein_1257 IS607 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1402592..1445506 42914
- flank IS/Tn - - 1414110..1414331 221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T180848 WP_011097988.1 NZ_CP064332:1409481-1409747 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T180848 NZ_CP085753:c3143449-3143150 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8615.63 Da        Isoelectric Point: 5.0958

>AT180848 WP_004091377.1 NZ_CP064332:1409270-1409497 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT180848 NZ_CP085753:c3143139-3142774 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7TPD2

References