Detailed information of TA system TA180846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1324356..1324887
• Replicon: chromosome
• Accession: NZ_CP064332
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: IUD21_RS05950
• Protein ID: WP_004090909.1
• Coordinates: 1324606..1324887 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: IUD21_RS05945
• Protein ID: WP_004090907.1
• Coordinates: 1324356..1324619 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD21_RS05920	1319582..1320760	-	1179	WP_011097931.1	phage tail sheath family protein	-
IUD21_RS05925	1320825..1322417	-	1593	WP_012382617.1	tail fiber domain-containing protein	-
IUD21_RS05930	1322425..1322982	-	558	WP_011097610.1	phage tail protein I	-
IUD21_RS05935	1322975..1323868	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
IUD21_RS05940	1323868..1324206	-	339	WP_004090694.1	GPW/gp25 family protein	-
IUD21_RS05945	1324356..1324619	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IUD21_RS05950	1324606..1324887	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IUD21_RS05955	1324924..1325511	-	588	WP_011097612.1	phage baseplate assembly protein V	-
IUD21_RS05960	1325508..1326050	-	543	WP_011097613.1	hypothetical protein	-
IUD21_RS05965	1326026..1326547	-	522	WP_011097614.1	hypothetical protein	-
IUD21_RS05970	1326544..1326867	-	324	WP_012382618.1	hypothetical protein	-
IUD21_RS05975	1326867..1327127	-	261	WP_012382619.1	hypothetical protein	-
IUD21_RS05980	1327145..1329019	-	1875	WP_012382620.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1310943..1357665	46722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T180846 WP_004090909.1 NZ_CP064332:1324606-1324887 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T180846 NZ_CP085753:2055551-2055922 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCGTGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTCACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT180846 WP_004090907.1 NZ_CP064332:1324356-1324619 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT180846 NZ_CP085753:2055306-2055548 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2