Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1581085..1581671 Replicon chromosome
Accession NZ_CP064330
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-13

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag IUD22_RS07145 Protein ID WP_004089517.1
Coordinates 1581417..1581671 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag IUD22_RS07140 Protein ID WP_004085025.1
Coordinates 1581085..1581420 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD22_RS07110 1576684..1577538 - 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -
IUD22_RS07115 1578030..1578803 + 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
IUD22_RS07120 1578800..1579264 + 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
IUD22_RS07125 1579251..1579964 - 714 WP_011098057.1 site-specific DNA-methyltransferase -
IUD22_RS07130 1580315..1580596 + 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUD22_RS07135 1580606..1580905 + 300 WP_004089519.1 HigA family addiction module antidote protein -
IUD22_RS07140 1581085..1581420 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IUD22_RS07145 1581417..1581671 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
IUD22_RS07150 1581724..1582422 - 699 WP_011098059.1 hypothetical protein -
IUD22_RS07155 1582551..1583012 - 462 WP_011098060.1 hypothetical protein -
IUD22_RS07160 1583009..1583772 - 764 Protein_1393 hypothetical protein -
IUD22_RS07165 1583678..1584784 - 1107 WP_012382665.1 YdaU family protein -
IUD22_RS07170 1584781..1585080 - 300 WP_080513037.1 hypothetical protein -
IUD22_RS07175 1585079..1585556 + 478 Protein_1396 conjugal transfer protein -
IUD22_RS07180 1585562..1586167 + 606 WP_004091108.1 conjugal transfer protein TrbN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1554173..1600925 46752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T180840 WP_004089517.1 NZ_CP064330:c1581671-1581417 [Xylella fastidiosa subsp. fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T180840 NZ_CP085753:266046-266519 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTGACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGCAGTGGTGCAAACCAGTATGGCGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTAGCTTCACTGGAAATTCTGGTGCACGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCCGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
ACAAAGCACTCAATTCTGTTGAATTAATGCCTTTTAATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT180840 WP_004085025.1 NZ_CP064330:c1581420-1581085 [Xylella fastidiosa subsp. fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT180840 NZ_CP085753:265606-266049 [Enterobacter hormaechei]
ATGAGAACATGGGTTCCTGCGCAAAGGCCGGCTGATAACACGCTGTGGCGCTACGCCGGTTTGCCTGCAAGCAGAGGCAT
GCGGCTGATAGAATATCTCAATCAAGGATTACCCGTCAGCGTCCTCGACAATATTCACGAGTGGACGGACATGTCGAAAG
CGGAGATTTTACGCGTCACGGGAATCAACGAGCGTAACGTTGCCCGCCGCAAAAGTACGGGCCGGACGCTGACGCCCGAC
GAGAGCGAACGTGTGGCGCGTTTCGTTCGGGTACTTGATGCGGCTGTCGATTATTTCGGCAGTAAAGAAGAGGCATGGAA
CTGGTTGCAGTTACCGGTACGTGGGCTTGGCAATGTTGCGCCTGTCGATCTGATCGCCACGGAAACCGGTGCGCTGGAAG
TTACCGATTTGATTGGTCGGCTGGAGCACGGAGTGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References