Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 1392030..1392507 | Replicon | chromosome |
| Accession | NZ_CP064330 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Bakersfield-13 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | Q87CA4 |
| Locus tag | IUD22_RS06290 | Protein ID | WP_011097988.1 |
| Coordinates | 1392241..1392507 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | A0A7G7TPD2 |
| Locus tag | IUD22_RS06285 | Protein ID | WP_004091377.1 |
| Coordinates | 1392030..1392257 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUD22_RS06245 | 1387157..1388302 | - | 1146 | WP_011097984.1 | baseplate J/gp47 family protein | - |
| IUD22_RS06250 | 1388401..1388697 | + | 297 | WP_004089252.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IUD22_RS06255 | 1388701..1389006 | + | 306 | WP_004089254.1 | putative addiction module antidote protein | - |
| IUD22_RS06260 | 1389017..1389370 | - | 354 | WP_011097986.1 | hypothetical protein | - |
| IUD22_RS06265 | 1389367..1390008 | - | 642 | WP_004090764.1 | hypothetical protein | - |
| IUD22_RS06270 | 1390005..1390835 | - | 831 | WP_004090766.1 | hypothetical protein | - |
| IUD22_RS06275 | 1390832..1391149 | - | 318 | WP_011097873.1 | hypothetical protein | - |
| IUD22_RS06280 | 1391149..1391919 | - | 771 | WP_004090769.1 | hypothetical protein | - |
| IUD22_RS06285 | 1392030..1392257 | + | 228 | WP_004091377.1 | hypothetical protein | Antitoxin |
| IUD22_RS06290 | 1392241..1392507 | + | 267 | WP_011097988.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IUD22_RS06295 | 1392518..1394407 | - | 1890 | WP_011097989.1 | hypothetical protein | - |
| IUD22_RS06300 | 1394364..1394528 | - | 165 | WP_014607750.1 | hypothetical protein | - |
| IUD22_RS06305 | 1394555..1394977 | - | 423 | WP_004085005.1 | hypothetical protein | - |
| IUD22_RS06310 | 1394974..1395411 | - | 438 | WP_011097990.1 | DUF3277 family protein | - |
| IUD22_RS06315 | 1395421..1395642 | - | 222 | Protein_1226 | DUF3383 family protein | - |
| IUD22_RS06320 | 1395671..1396876 | - | 1206 | Protein_1227 | transposase | - |
| IUD22_RS06325 | 1396870..1397475 | - | 606 | Protein_1228 | IS607 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1385352..1403651 | 18299 | |
| - | flank | IS/Tn | - | - | 1396870..1397091 | 221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10163.79 Da Isoelectric Point: 10.6086
>T180839 WP_011097988.1 NZ_CP064330:1392241-1392507 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
Download Length: 267 bp
>T180839 NZ_CP085753:c156171-155650 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAGCGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTGGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAGCGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTGGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8615.63 Da Isoelectric Point: 5.0958
>AT180839 WP_004091377.1 NZ_CP064330:1392030-1392257 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
Download Length: 228 bp
>AT180839 NZ_CP085753:c156447-156178 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGAATGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGAATGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HDH1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7TPD2 |