Detailed information of TA system TA180837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1307117..1307648
• Replicon: chromosome
• Accession: NZ_CP064330
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: IUD22_RS05815
• Protein ID: WP_004090909.1
• Coordinates: 1307367..1307648 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: IUD22_RS05810
• Protein ID: WP_004090907.1
• Coordinates: 1307117..1307380 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD22_RS05785	1302344..1303522	-	1179	WP_011097931.1	phage tail sheath family protein	-
IUD22_RS05790	1303587..1305179	-	1593	WP_012382617.1	tail fiber domain-containing protein	-
IUD22_RS05795	1305187..1305744	-	558	WP_011097610.1	phage tail protein I	-
IUD22_RS05800	1305737..1306629	-	893	Protein_1123	baseplate J/gp47 family protein	-
IUD22_RS05805	1306629..1306967	-	339	WP_004090694.1	GPW/gp25 family protein	-
IUD22_RS05810	1307117..1307380	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IUD22_RS05815	1307367..1307648	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IUD22_RS05820	1307685..1308272	-	588	WP_011097612.1	phage baseplate assembly protein V	-
IUD22_RS05825	1308269..1308811	-	543	WP_011097613.1	hypothetical protein	-
IUD22_RS05830	1308787..1309308	-	522	WP_011097614.1	hypothetical protein	-
IUD22_RS05835	1309305..1309628	-	324	WP_012382618.1	hypothetical protein	-
IUD22_RS05840	1309628..1309888	-	261	WP_012382619.1	hypothetical protein	-
IUD22_RS05845	1309906..1311780	-	1875	WP_012382620.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1293705..1340425	46720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T180837 WP_004090909.1 NZ_CP064330:1307367-1307648 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T180837 NZ_CP085751:11888-12304 [Enterobacter hormaechei]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT180837 WP_004090907.1 NZ_CP064330:1307117-1307380 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT180837 NZ_CP085751:11661-11891 [Enterobacter hormaechei]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2