Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2508886..2509497 Replicon chromosome
Accession NZ_CP064328
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-14

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag IUD25_RS11150 Protein ID WP_011098375.1
Coordinates 2509198..2509497 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag IUD25_RS11145 Protein ID WP_004085003.1
Coordinates 2508886..2509194 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD25_RS11115 2505456..2506217 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
IUD25_RS11140 2507409..2508812 + 1404 WP_011098374.1 hypothetical protein -
IUD25_RS11145 2508886..2509194 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
IUD25_RS11150 2509198..2509497 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUD25_RS11155 2509585..2510130 + 546 WP_011098376.1 hypothetical protein -
IUD25_RS11160 2510142..2510285 + 144 WP_155115087.1 hypothetical protein -
IUD25_RS11165 2510438..2510818 - 381 WP_004089371.1 DUF596 domain-containing protein -
IUD25_RS11170 2510823..2511953 - 1131 WP_012382788.1 DUF769 domain-containing protein -
IUD25_RS11175 2512261..2512641 - 381 WP_004087391.1 DUF596 domain-containing protein -
IUD25_RS11180 2512653..2514227 - 1575 Protein_2176 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2459685..2515763 56078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T180832 WP_011098375.1 NZ_CP064328:c2509497-2509198 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T180832 NZ_CP085748:c3323515-3323412 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT180832 WP_004085003.1 NZ_CP064328:c2509194-2508886 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT180832 NZ_CP085748:3323399-3323607 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAA
AAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAGCCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References