Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 1391766..1392243 | Replicon | chromosome |
| Accession | NZ_CP064328 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Bakersfield-14 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | Q87CA4 |
| Locus tag | IUD25_RS06285 | Protein ID | WP_011097988.1 |
| Coordinates | 1391977..1392243 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | A0A7G7TPD2 |
| Locus tag | IUD25_RS06280 | Protein ID | WP_004091377.1 |
| Coordinates | 1391766..1391993 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUD25_RS06240 | 1386893..1388038 | - | 1146 | WP_011097984.1 | baseplate J/gp47 family protein | - |
| IUD25_RS06245 | 1388137..1388433 | + | 297 | WP_004089252.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IUD25_RS06250 | 1388437..1388742 | + | 306 | WP_004089254.1 | putative addiction module antidote protein | - |
| IUD25_RS06255 | 1388753..1389106 | - | 354 | WP_011097986.1 | hypothetical protein | - |
| IUD25_RS06260 | 1389103..1389744 | - | 642 | WP_004090764.1 | hypothetical protein | - |
| IUD25_RS06265 | 1389741..1390571 | - | 831 | WP_004090766.1 | hypothetical protein | - |
| IUD25_RS06270 | 1390568..1390885 | - | 318 | WP_011097873.1 | hypothetical protein | - |
| IUD25_RS06275 | 1390885..1391655 | - | 771 | WP_004090769.1 | hypothetical protein | - |
| IUD25_RS06280 | 1391766..1391993 | + | 228 | WP_004091377.1 | hypothetical protein | Antitoxin |
| IUD25_RS06285 | 1391977..1392243 | + | 267 | WP_011097988.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IUD25_RS06290 | 1392254..1393648 | - | 1395 | WP_194957424.1 | hypothetical protein | - |
| IUD25_RS06295 | 1393672..1394142 | - | 471 | WP_194957409.1 | hypothetical protein | - |
| IUD25_RS06300 | 1394290..1394712 | - | 423 | WP_004085005.1 | hypothetical protein | - |
| IUD25_RS06305 | 1394709..1395146 | - | 438 | WP_011097990.1 | DUF3277 family protein | - |
| IUD25_RS06310 | 1395156..1395377 | - | 222 | Protein_1225 | DUF3383 family protein | - |
| IUD25_RS06315 | 1395406..1396611 | - | 1206 | Protein_1226 | transposase | - |
| IUD25_RS06320 | 1396605..1397210 | - | 606 | Protein_1227 | IS607 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1385088..1403386 | 18298 | |
| - | flank | IS/Tn | - | - | 1396605..1396826 | 221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10163.79 Da Isoelectric Point: 10.6086
>T180830 WP_011097988.1 NZ_CP064328:1391977-1392243 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
Download Length: 267 bp
>T180830 NZ_CP085748:c1606024-1605725 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8615.63 Da Isoelectric Point: 5.0958
>AT180830 WP_004091377.1 NZ_CP064328:1391766-1391993 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
Download Length: 228 bp
>AT180830 NZ_CP085748:c1605714-1605349 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HDH1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7TPD2 |