Detailed information of TA system TA180828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1306854..1307385
• Replicon: chromosome
• Accession: NZ_CP064328
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: IUD25_RS05800
• Protein ID: WP_004090909.1
• Coordinates: 1307104..1307385 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: IUD25_RS05795
• Protein ID: WP_004090907.1
• Coordinates: 1306854..1307117 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD25_RS05770	1302080..1303258	-	1179	WP_011097931.1	phage tail sheath family protein	-
IUD25_RS05775	1303323..1304915	-	1593	WP_012382617.1	tail fiber domain-containing protein	-
IUD25_RS05780	1304923..1305480	-	558	WP_011097610.1	phage tail protein I	-
IUD25_RS05785	1305473..1306366	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
IUD25_RS05790	1306366..1306704	-	339	WP_004090694.1	GPW/gp25 family protein	-
IUD25_RS05795	1306854..1307117	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IUD25_RS05800	1307104..1307385	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IUD25_RS05805	1307422..1308009	-	588	WP_011097612.1	phage baseplate assembly protein V	-
IUD25_RS05810	1308006..1308548	-	543	WP_011097613.1	hypothetical protein	-
IUD25_RS05815	1308524..1309045	-	522	WP_011097614.1	hypothetical protein	-
IUD25_RS05820	1309042..1309365	-	324	WP_012382618.1	hypothetical protein	-
IUD25_RS05825	1309365..1309625	-	261	WP_012382619.1	hypothetical protein	-
IUD25_RS05830	1309643..1311517	-	1875	WP_012382620.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1293441..1340161	46720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T180828 WP_004090909.1 NZ_CP064328:1307104-1307385 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T180828 NZ_CP085748:518120-518491 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCGTGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTCACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT180828 WP_004090907.1 NZ_CP064328:1306854-1307117 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT180828 NZ_CP085748:517875-518117 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2