Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/Fic(toxin) |
| Location | 1215982..1216778 | Replicon | chromosome |
| Accession | NZ_CP064328 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Bakersfield-14 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | Q87CQ8 |
| Locus tag | IUD25_RS05300 | Protein ID | WP_004088112.1 |
| Coordinates | 1215982..1216593 (-) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | B2I551 |
| Locus tag | IUD25_RS05305 | Protein ID | WP_004088114.1 |
| Coordinates | 1216590..1216778 (-) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUD25_RS05255 | 1211437..1212324 | - | 888 | WP_012382597.1 | YdaU family protein | - |
| IUD25_RS05260 | 1212321..1213109 | - | 789 | WP_011097897.1 | Bro-N domain-containing protein | - |
| IUD25_RS05265 | 1213106..1213738 | - | 633 | WP_004088094.1 | Bro-N domain-containing protein | - |
| IUD25_RS05270 | 1213735..1214019 | - | 285 | WP_004088096.1 | hypothetical protein | - |
| IUD25_RS05275 | 1214016..1214264 | - | 249 | WP_011097898.1 | hypothetical protein | - |
| IUD25_RS05280 | 1214261..1214449 | - | 189 | WP_004088102.1 | hypothetical protein | - |
| IUD25_RS05285 | 1214477..1214668 | - | 192 | WP_004088104.1 | hypothetical protein | - |
| IUD25_RS05290 | 1214927..1215172 | - | 246 | WP_004088108.1 | hypothetical protein | - |
| IUD25_RS05295 | 1215257..1215931 | + | 675 | WP_012382600.1 | helix-turn-helix transcriptional regulator | - |
| IUD25_RS05300 | 1215982..1216593 | - | 612 | WP_004088112.1 | Fic/DOC family protein | Toxin |
| IUD25_RS05305 | 1216590..1216778 | - | 189 | WP_004088114.1 | antitoxin VbhA family protein | Antitoxin |
| IUD25_RS05310 | 1217170..1217706 | + | 537 | WP_012382601.1 | hypothetical protein | - |
| IUD25_RS05315 | 1217703..1218116 | + | 414 | WP_004088056.1 | DUF1566 domain-containing protein | - |
| IUD25_RS05320 | 1218113..1218514 | + | 402 | WP_004088054.1 | hypothetical protein | - |
| IUD25_RS05325 | 1218511..1218660 | + | 150 | WP_012382602.1 | hypothetical protein | - |
| IUD25_RS05330 | 1218746..1219024 | + | 279 | WP_004088050.1 | hypothetical protein | - |
| IUD25_RS05335 | 1219047..1219238 | + | 192 | WP_012382603.1 | hypothetical protein | - |
| IUD25_RS05340 | 1219259..1219603 | + | 345 | WP_004088346.1 | hypothetical protein | - |
| IUD25_RS05345 | 1219643..1220464 | + | 822 | WP_004088345.1 | DUF2303 family protein | - |
| IUD25_RS05350 | 1220480..1221406 | + | 927 | WP_004088344.1 | phage recombination protein Bet | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1203079..1226528 | 23449 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22832.60 Da Isoelectric Point: 5.1271
>T180827 WP_004088112.1 NZ_CP064328:c1216593-1215982 [Xylella fastidiosa subsp. fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
Download Length: 612 bp
>T180827 NZ_CP085748:132050-132337 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6837.77 Da Isoelectric Point: 4.9859
>AT180827 WP_004088114.1 NZ_CP064328:c1216778-1216590 [Xylella fastidiosa subsp. fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
Download Length: 189 bp
>AT180827 NZ_CP085748:131741-132043 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|