Detailed information of TA system TA180821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1365110..1365587
• Replicon: chromosome
• Accession: NZ_CP064326
• Organism: Xylella fastidiosa subsp. multiplex strain Riv5

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: IUD19_RS06065
• Protein ID: WP_004087087.1
• Coordinates: 1365321..1365587 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: IUD19_RS06060
• Protein ID: WP_004091377.1
• Coordinates: 1365110..1365337 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD19_RS06020	1360201..1361346	-	1146	WP_194957573.1	baseplate J/gp47 family protein	-
IUD19_RS06025	1361449..1361745	+	297	WP_004085590.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IUD19_RS06030	1361748..1362041	+	294	WP_004085592.1	putative addiction module antidote protein	-
IUD19_RS06035	1362097..1362450	-	354	WP_004084998.1	hypothetical protein	-
IUD19_RS06040	1362447..1363088	-	642	WP_140189635.1	hypothetical protein	-
IUD19_RS06045	1363085..1363915	-	831	WP_004085594.1	hypothetical protein	-
IUD19_RS06050	1363912..1364229	-	318	WP_169710077.1	hypothetical protein	-
IUD19_RS06055	1364229..1364999	-	771	WP_169710321.1	hypothetical protein	-
IUD19_RS06060	1365110..1365337	+	228	WP_004091377.1	hypothetical protein	Antitoxin
IUD19_RS06065	1365321..1365587	+	267	WP_004087087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUD19_RS06070	1365598..1367487	-	1890	WP_194957574.1	hypothetical protein	-
IUD19_RS06075	1367635..1368057	-	423	WP_194957575.1	hypothetical protein	-
IUD19_RS06080	1368054..1368491	-	438	WP_004085006.1	DUF3277 family protein	-
IUD19_RS06085	1368501..1369997	-	1497	WP_128283792.1	DUF3383 domain-containing protein	-
IUD19_RS06090	1369998..1370531	-	534	WP_004085008.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1355747..1389767	34020

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10207.80 Da
• Isoelectric Point: 10.3398

>T180821 WP_004087087.1 NZ_CP064326:1365321-1365587 [Xylella fastidiosa subsp. multiplex]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCDIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T180821 NZ_CP085746:53378-53863 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT180821 WP_004091377.1 NZ_CP064326:1365110-1365337 [Xylella fastidiosa subsp. multiplex]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT180821 NZ_CP085746:53124-53390 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7G7TPD2