Detailed information of TA system TA180815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1630771..1631293
• Replicon: chromosome
• Accession: NZ_CP064325
• Organism: Xylella fastidiosa subsp. multiplex strain Red Oak

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IUD24_RS07280
• Protein ID: WP_004085905.1
• Coordinates: 1631006..1631293 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A060HDF9
• Locus tag: IUD24_RS07275
• Protein ID: WP_004085758.1
• Coordinates: 1630771..1631013 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD24_RS07245	1626181..1626363	+	183	WP_027700467.1	hypothetical protein	-
IUD24_RS07250	1626647..1627573	-	927	WP_004085766.1	Grx4 family monothiol glutaredoxin	-
IUD24_RS07255	1627639..1628415	+	777	WP_027700469.1	polysaccharide deacetylase family protein	-
IUD24_RS07260	1629059..1629250	-	192	WP_021358405.1	hypothetical protein	-
IUD24_RS07265	1629668..1630087	-	420	WP_004085763.1	putative toxin-antitoxin system toxin component, PIN family	-
IUD24_RS07270	1630087..1630326	-	240	WP_004085761.1	ribbon-helix-helix domain-containing protein	-
IUD24_RS07275	1630771..1631013	+	243	WP_004085758.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
IUD24_RS07280	1631006..1631293	+	288	WP_004085905.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUD24_RS07285	1631381..1631947	+	567	WP_004085755.1	recombinase family protein	-
IUD24_RS07290	1632000..1633196	-	1197	WP_012337730.1	transposase	-
IUD24_RS07295	1633190..1633816	-	627	WP_038230952.1	IS607 family transposase	-
IUD24_RS07300	1634046..1635320	-	1275	WP_012337985.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1629265..1650562	21297
	-	flank	IS/Tn	-	-	1631381..1631947	566

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11159.64 Da
• Isoelectric Point: 5.9570

>T180815 WP_004085905.1 NZ_CP064325:1631006-1631293 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Nucleotide

• Length: 288 bp

>T180815 NZ_CP085743:c3102301-3102014 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8774.77 Da
• Isoelectric Point: 6.9881

>AT180815 WP_004085758.1 NZ_CP064325:1630771-1631013 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Nucleotide

• Length: 243 bp

>AT180815 NZ_CP085743:c3102610-3102308 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A060HDF9