Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2393..2940 Replicon plasmid pSLT7_2
Accession NZ_CP064265
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LT7

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag ITP16_RS23760 Protein ID WP_000969997.1
Coordinates 2659..2940 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag ITP16_RS23755 Protein ID WP_000079932.1
Coordinates 2393..2662 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITP16_RS23750 454..1485 + 1032 WP_001690254.1 replication initiation protein -
ITP16_RS23755 2393..2662 + 270 WP_000079932.1 hypothetical protein Antitoxin
ITP16_RS23760 2659..2940 + 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITP16_RS23765 3136..3477 - 342 WP_000578011.1 hypothetical protein -
ITP16_RS23770 3777..4364 + 588 WP_024189984.1 serine acetyltransferase -
ITP16_RS23775 4646..5239 - 594 WP_000517696.1 hypothetical protein -
ITP16_RS23780 5593..6939 + 1347 WP_032082920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..88171 88171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T180790 WP_000969997.1 NZ_CP064265:2659-2940 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T180790 NZ_CP085729:3934023-3934307 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT180790 WP_000079932.1 NZ_CP064265:2393-2662 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT180790 NZ_CP085729:3933791-3934033 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References