Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4189961..4190580 Replicon chromosome
Accession NZ_CP064258
Organism Klebsiella pneumoniae strain JX-CR-hvKP-10

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IS497_RS20825 Protein ID WP_002892050.1
Coordinates 4190362..4190580 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IS497_RS20820 Protein ID WP_002892066.1
Coordinates 4189961..4190335 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS497_RS20810 4185113..4186306 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IS497_RS20815 4186329..4189475 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
IS497_RS20820 4189961..4190335 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IS497_RS20825 4190362..4190580 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IS497_RS20830 4190739..4191305 + 567 WP_002892030.1 maltose O-acetyltransferase -
IS497_RS20835 4191277..4191417 - 141 WP_004147370.1 hypothetical protein -
IS497_RS20840 4191438..4191908 + 471 WP_002892026.1 YlaC family protein -
IS497_RS20845 4191883..4193334 - 1452 WP_194810507.1 PLP-dependent aminotransferase family protein -
IS497_RS20850 4193435..4194133 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
IS497_RS20855 4194130..4194270 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IS497_RS20860 4194270..4194533 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T180768 WP_002892050.1 NZ_CP064258:4190362-4190580 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T180768 NZ_CP085699:c4141473-4141186 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT180768 WP_002892066.1 NZ_CP064258:4189961-4190335 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT180768 NZ_CP085699:c4141199-4140897 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References