Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5081667..5083348 Replicon chromosome
Accession NZ_CP064252
Organism Klebsiella pneumoniae strain JX-CR-hvKP-1

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag IS496_RS25125 Protein ID WP_002885155.1
Coordinates 5081667..5082584 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag IS496_RS25130 Protein ID WP_004151732.1
Coordinates 5082590..5083348 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS496_RS25105 5076973..5078493 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
IS496_RS25110 5078490..5079488 + 999 WP_002885172.1 ribose ABC transporter permease -
IS496_RS25115 5079519..5080460 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
IS496_RS25120 5080535..5081542 + 1008 WP_004151731.1 carbohydrate kinase family protein -
IS496_RS25125 5081667..5082584 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IS496_RS25130 5082590..5083348 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
IS496_RS25135 5083434..5084162 - 729 WP_002885152.1 response regulator transcription factor -
IS496_RS25140 5084435..5086582 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
IS496_RS25145 5086812..5087498 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T180742 WP_002885155.1 NZ_CP064252:c5082584-5081667 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T180742 NZ_CP085688:c4376577-4375258 [Providencia rettgeri]
ATGGCGACTTTGCATGTATACATGAATGGTTACTTGGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
ATATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGTCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCTTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGCGAATGCTCCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAATATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCCTATAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCGGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTAGGTTCAATAAATGCGGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAGGTTTTGTTTTGGTTACTTGCAGCGACGGATGGCCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGGTTGAAGGGAACAAGGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTATTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT180742 WP_004151732.1 NZ_CP064252:c5083348-5082590 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT180742 NZ_CP085688:c4376834-4376577 [Providencia rettgeri]
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGATGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGTAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTCGATATTAAACCGCGAAATGAAAGTGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References