Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4209609..4210228 Replicon chromosome
Accession NZ_CP064252
Organism Klebsiella pneumoniae strain JX-CR-hvKP-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IS496_RS20900 Protein ID WP_002892050.1
Coordinates 4210010..4210228 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IS496_RS20895 Protein ID WP_002892066.1
Coordinates 4209609..4209983 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS496_RS20885 4204761..4205954 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IS496_RS20890 4205977..4209123 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
IS496_RS20895 4209609..4209983 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IS496_RS20900 4210010..4210228 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IS496_RS20905 4210387..4210953 + 567 WP_002892030.1 maltose O-acetyltransferase -
IS496_RS20910 4210925..4211065 - 141 WP_004147370.1 hypothetical protein -
IS496_RS20915 4211086..4211556 + 471 WP_002892026.1 YlaC family protein -
IS496_RS20920 4211531..4212982 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IS496_RS20925 4213083..4213781 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
IS496_RS20930 4213778..4213918 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IS496_RS20935 4213918..4214181 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T180739 WP_002892050.1 NZ_CP064252:4210010-4210228 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T180739 NZ_CP085688:c3993464-3993147 [Providencia rettgeri]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGAAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT180739 WP_002892066.1 NZ_CP064252:4209609-4209983 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT180739 NZ_CP085688:c3993732-3993445 [Providencia rettgeri]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAACAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TCAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References