Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 110783..111693 Replicon plasmid pJX3-1
Accession NZ_CP064242
Organism Klebsiella pneumoniae strain JX-CR-hvKP-3

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag IS502_RS27010 Protein ID WP_004026354.1
Coordinates 111223..111693 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag IS502_RS27005 Protein ID WP_004026357.1
Coordinates 110783..111226 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS502_RS26980 106292..107194 + 903 WP_004213613.1 DMT family transporter -
IS502_RS26985 107337..107558 - 222 WP_004213615.1 hypothetical protein -
IS502_RS26990 107620..108927 - 1308 Protein_122 FepA family TonB-dependent siderophore receptor -
IS502_RS26995 108993..109973 + 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
IS502_RS27000 110179..110682 + 504 Protein_124 DUF4113 domain-containing protein -
IS502_RS27005 110783..111226 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
IS502_RS27010 111223..111693 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
IS502_RS27015 111842..112539 + 698 Protein_127 IS1 family transposase -
IS502_RS27020 113925..114874 - 950 Protein_128 DUF1173 family protein -
IS502_RS27025 115052..115546 + 495 WP_004212794.1 thermonuclease family protein -
IS502_RS27030 115883..116281 + 399 WP_004212796.1 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / rmpA / iroN 1..221242 221242
- inside IScluster/Tn - rmpA / rmpA / iroN 98420..117732 19312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T180686 WP_004026354.1 NZ_CP064242:111223-111693 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T180686 NZ_CP085636:c5573712-5572411 [Shewanella sp. MTB7]
ATGGCGGATTCTGTAAATCTCGTTTTAGATATGCATCTCGGTGAGCAAATTATCGGTGAGCTGTCATTCGATACCGCTAC
TGAGACATTTGCTGTTAACTATACCAATGATTGGCAACAACGTGGTTTTCCTATATCGCCCATGATTCCTCTAGATGGCA
GTGGGCGTAGCAATCAAATCTCAATGTTCTTGGTTAATTTGCTTCCTGAGAATAAGGGGCTCGATTACCTTATTGAATCG
CTAGGTGTGTCTAGGGGGAACACCTTTGCACTTGTCCGTGGCATTGGTCTCGACACCGCTGGTGCAATCGCCTTTTCTCT
TAAAGAATCATTACTACCTGAGACGTCATTCAGAGCAATAAGCGATGCAGAAGTCATTAAGCGCCTCGAAGACCCTGATA
GTTGGCCAATGGAAGTATGGGATGGTAAGCCAAGGCTGTCGGTAGCAGGTGTACAGTCAAAACTAAACCTATTTTATAAC
GGTAAAGCATTTGGTTTTGCTGAAGGCGCGCTTTCATCAACACACATTCTAAAGTTTGAAAAGCATCAACATTTAGTTAT
TAATGAATTTTTGACCATGCGTTTGGCTAAGGCCATATCAATGCATGTGGCAAACGTAGAAATCAGCTACTTTGGTCAAT
ATAAAGCACTATGTGTTGAACGCTTTGATCGTCGCTATCTGCCTGATGAGCATAAAGTGCTTAGACGGCATATTATCGAT
AGCTGCCAAACACTCGGATTTAGCGTTAACAAAAAGTATGAGCGTAATTTTGGTGCTGGCCACGATGTGAGAGATATCCG
CGAGGGCGTTAGCTTTGCAAGACTATTTGGTTTAGCGAGCCAGTGCAGTAATCCGGCTGCGGCTAAGCAAGATATGCTGC
AGTGGGCGCTATTTAATTTACTTAGCGGTAATGCTGATGCTCACGGTAAAAACTACTCATTCTTTATGACGCCAGAAGGT
CTCGTGCCTACGCCATGGTACGACTTGGTATGTGTAACGCTGTACGATGAATTTGAGCAAGAGATGGCAATGGCGATAGA
TGATGAATTTGATCCCAACAAGATCTACGCTTATCAGCTAGCCTCGTTTATTGAAGATATAGGCCTGCCAAGGACTTTAC
TTATCAATAATTTAACTCAAATGGCGACTAAGATAACCCAAGTCATAGATAACGTTATAGTAATGCTTCCTGCACTTGAT
AAAGCCGAGCAAGACTTTGTCGATGCATACAAAGCACTGCTACTGGCTAGGTGCGAACGCTATCTAGCTAGCGCTGCAGA
AATCAAAAATATTGAATTGTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT180686 WP_004026357.1 NZ_CP064242:110783-111226 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT180686 NZ_CP085636:c5573952-5573716 [Shewanella sp. MTB7]
ATGGGGCCTACGCTAAATCAACAATCCTTGGGTTTACTGGTTAAAGAAAACAGAAAAAAAGCTGGGCTTACTCAAGAGGT
GGCCGCCATGTTGTGCGGTGTCACTAAAAAGACTTTTATTCGAGTAGAGAAAGGTGAAGACGTTTATATCTCTACCGTGT
TTAAAATCCTTGATGGTTTGGGTGTCGCTATTGTTGCTAAGCAAAACAGCACGACTAATGCTAGCGGGTGGTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References