Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4976064..4977745 Replicon chromosome
Accession NZ_CP064241
Organism Klebsiella pneumoniae strain JX-CR-hvKP-3

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag IS502_RS24515 Protein ID WP_002885155.1
Coordinates 4976064..4976981 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag IS502_RS24520 Protein ID WP_004151732.1
Coordinates 4976987..4977745 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS502_RS24495 4971370..4972890 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
IS502_RS24500 4972887..4973885 + 999 WP_002885172.1 ribose ABC transporter permease -
IS502_RS24505 4973916..4974857 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
IS502_RS24510 4974932..4975939 + 1008 WP_004151731.1 carbohydrate kinase family protein -
IS502_RS24515 4976064..4976981 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IS502_RS24520 4976987..4977745 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
IS502_RS24525 4977831..4978559 - 729 WP_002885152.1 response regulator transcription factor -
IS502_RS24530 4978832..4980979 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
IS502_RS24535 4981209..4981895 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T180683 WP_002885155.1 NZ_CP064241:c4976981-4976064 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T180683 NZ_CP085636:444369-445691 [Shewanella sp. MTB7]
ATGGCTGTTCTGGATGTTTATGTGAATGGCTATCTGGTAGGTGAATTTACTAAATCGACCACAGGCTCTCATCTGTTTAA
GTACGCCCCCAAATGGCTAACAACACCTGGAAGTCGGCCTATTTCATTGTCGATGCCATTGCGATCGCAAGCGTATAAAG
GCGATGAAGTTTATAACTTCTTTGATAACTTACTACCAGATAACATGGAGGTGAGAAACAGGATTGTTGCTCGTCATAAT
GCGCAATCGACACAAGCGTTCGATCTACTCGCTAAAGTCGGCCAAGACAGTGTCGGTGCATTGCAGTTAGTACTTCATGG
TCAACACCCTTTTGATGTTAAAAAGATTGAAGCTAAAGATTTATCCGATGAGGCATTGGAAAAAGTGCTCAAAGGTTATC
AGTCAGATATTCCGTTAGGCATGCTAGTCGATGAAGATGATTTTCGAATATCGATTGCAGGTGCCCAAGAGAAGACCGCC
TTACTTAATTTAGATGGCCGATGGCAACTCCCTATTAAAGCTACACCGACTACGCATATCATTAAGCTGCCTATCGGTGA
GATACAGAGCCATTCATATACCATCGATATGAATGACAGCGTTGAAAATGAATACCTGTGCATGATGATAGTGAGGGAGT
TTGGCTTAGATGTACCTCATTGCTCAATACTCAAAGTGGGTGATATTAAAGCGCTAGCAGTAGCGCGCTTTGATCGTAAA
TTATCCAGTGATGGCCAATGGATAATGCGATTGCCGCAAGAGGATTTTTGTCAGACGTTAAATATTCCACCTGCAAAAAA
ATATGAAAGTCATGGTGGTCCCGGTATTGAACAAATCATGCTTTATCTACTCGGCTCTATGAACTCAGAGCGAGATAGGT
ACAACTTAATGAAGTCACAAGTGTTGTTTTGGTTATTAGCAGCTACAGATGGGCATGCTAAAAACTTTTCTCTTTTCATC
GAGGTTGGTGGCGGATATCGATTAACCCCTTTTTACGACATTATATCCATGTACCCAGTGATAGGCGGCAAGGGGTTAAA
TATTCGCGATGCAAAGTTGGCTATGGGGCTTAAGGCGACCAAAGGTAAGAAGTATCAAATTGCTCAGATTTTTCCACGGC
ACTTTCTGCAAACAGCGAAGGCGGTAGGTTTTGATCTCGATGCTATGGTTGATATTTTGCGAGAGGTGGCAGATTCAGTT
GATGATGTGATTATGAGGGTAAAGGCTCAGTTGCCCGAAGACTTTCCTGTACATATAAGGGATTCTATTCTCGATGGTTT
AAAGGATAGAGCAAAGCGACTGATAGCTGAGTCATATATCTGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT180683 WP_004151732.1 NZ_CP064241:c4977745-4976987 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT180683 NZ_CP085636:444088-444369 [Shewanella sp. MTB7]
ATGAAGGTGACGAACTCAAAGCAGCTTAGCGCGTATCTCAAAGATGCACGATTGAATATGAAGCTCTCGCAAAGCAAAGT
GGGTAGTAAAGTCGGTATCCGTCAGGATACCGTTTCAAGCTTTGAACAGAACCCTGACTCCACCAAGTTAGAGACGCTGT
TTAAAATCCTGTCAGCACTGAATCTAGAGTTGGATATAAAGGTTAGAAACTCAGAGCTAACGGAGCAGCTTAATGATGAT
AAAAGCGCCGCCTCCGAGCAAGAGTGGAAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References