Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4819880..4820396 Replicon chromosome
Accession NZ_CP064241
Organism Klebsiella pneumoniae strain JX-CR-hvKP-3

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IS502_RS23715 Protein ID WP_002886902.1
Coordinates 4819880..4820164 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IS502_RS23720 Protein ID WP_002886901.1
Coordinates 4820154..4820396 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS502_RS23690 4815364..4815672 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IS502_RS23695 4815757..4815930 + 174 WP_002886906.1 hypothetical protein -
IS502_RS23700 4815933..4816676 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IS502_RS23705 4817033..4819171 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IS502_RS23710 4819412..4819876 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IS502_RS23715 4819880..4820164 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS502_RS23720 4820154..4820396 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IS502_RS23725 4820474..4822384 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IS502_RS23730 4822407..4823561 - 1155 WP_002886900.1 lactonase family protein -
IS502_RS23735 4823627..4824367 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T180682 WP_002886902.1 NZ_CP064241:c4820164-4819880 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180682 NZ_CP085633:4614592-4614879 [Pectobacterium brasiliense]
ATGAGCTATAGCGTCAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCGGCAAAGTTACGAGGGATGGAGGACTGCTACAAAATAA
AGCTCCGAGCGTCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGATTATCGCCGTAGTGGCGGTAGGCAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180682 WP_002886901.1 NZ_CP064241:c4820396-4820154 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180682 NZ_CP085633:4614344-4614595 [Pectobacterium brasiliense]
ATGCCGAATATTATATTGAGTGATACCACTGCCAGCGTCAGTGAACTGAAAAAGAACCCAATGGCGACGGTCAATGCTGG
CGATGGCCTGCCTGTTGCTATCTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTTGTTAAGCTAATCGGTGAACGCAAAAACCAACCGCTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References