Detailed information of TA system TA180679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2741191..2742779
• Replicon: chromosome
• Accession: NZ_CP064241
• Organism: Klebsiella pneumoniae strain JX-CR-hvKP-3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0H3GN97
• Locus tag: IS502_RS13560
• Protein ID: WP_004199851.1
• Coordinates: 2741191..2742513 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: IS502_RS13565
• Protein ID: WP_002904790.1
• Coordinates: 2742513..2742779 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IS502_RS13545	2736256..2738757	+	2502	WP_004199853.1	fimbrial biogenesis outer membrane usher protein	-
IS502_RS13550	2738745..2739749	+	1005	WP_004199852.1	type 1 fimbrial protein	-
IS502_RS13555	2739882..2741174	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
IS502_RS13560	2741191..2742513	-	1323	WP_004199851.1	type II toxin-antitoxin system HipA family toxin	Toxin
IS502_RS13565	2742513..2742779	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IS502_RS13570	2743045..2743371	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
IS502_RS13575	2743368..2743868	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IS502_RS13580	2743846..2745225	-	1380	WP_004199850.1	purine permease	-
IS502_RS13585	2745571..2746725	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
IS502_RS13590	2746706..2747629	-	924	WP_004199849.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtC / iroE	2536185..2785145	248960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49128.44 Da
• Isoelectric Point: 7.2487

>T180679 WP_004199851.1 NZ_CP064241:c2742513-2741191 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T180679 NZ_CP085633:3315626-3315970 [Pectobacterium brasiliense]
ATGAAATCACTCTACTGGGTTGGCAGTAGCAAAAAGGATCTCCAGTCGCTACCTGCTGATGTGCAGGATGTGTTCGGTTA
CGCACTTCATGTGGCTCAGACTGGTGGTAAGCACACTCAAGCCAGGCCGCTTAAAGGTTTTGGTGGTGCAGGCGTATTAG
AAGTCGTTGAGGATTATATCGGCGATACTTATCGCGCAGTCTACACCGTCAAATTTGGAGAGGCAGTATACGTTCTACAT
GCTTTTCAGAAAAAATCGTCATCTGGAATTGCAACACCGAAACCCGATATGAACACCATTCGTGAACGCCTTAAAGCCGC
AGAGAACCATGCAAAAGGAGCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT180679 WP_002904790.1 NZ_CP064241:c2742779-2742513 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT180679 NZ_CP085633:3315972-3316289 [Pectobacterium brasiliense]
ATGAGCCAGGATATTGAAGTCAGCAGCGGTAATGTGTACGCCGACCTTGGCAACGTGCATGCTGAAGATATGTTGGTCAA
AGCGCAGCTTGCCACACTGATTAGCTCAATCATCAAAAGCCGCCGTCTCACACAGGCAGAAGCAGCGAAGCTATTGGGCA
TGCCCCAACCAAAACTATCCAACTTATTACGTGGTCAGTTCAGGGGAATCAGCGAAACCAAAATGCTGGAATGCCTTACG
AAGCTGGGACGCGATATACAGATCGTTGTAGGGAAGCCGCGCCGCACACCGGGTAGCGTTAAAGTCGTGTTTGCGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GN97

Antitoxin

• AlphaFold DB: A0A0H3GXD8