180665

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 7727..8307 Replicon plasmid pJX4-4
Accession NZ_CP064239
Organism Klebsiella pneumoniae strain JX-CR-hvKP-4

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag IS499_RS29740 Protein ID WP_071177730.1
Coordinates 7727..8041 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag IS499_RS29745 Protein ID WP_000093040.1
Coordinates 8029..8307 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS499_RS29715 3671..5635 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
IS499_RS29720 5635..6366 + 732 WP_071177728.1 replication-relaxation family protein -
IS499_RS29725 6373..6903 + 531 WP_071177729.1 hypothetical protein -
IS499_RS29730 6930..7109 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
IS499_RS29735 7135..7563 - 429 WP_001140599.1 hypothetical protein -
IS499_RS29740 7727..8041 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS499_RS29745 8029..8307 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
IS499_RS29750 8641..8847 - 207 Protein_10 TonB family protein -
IS499_RS29755 8844..9215 - 372 WP_001237044.1 cell envelope integrity protein TolA -
IS499_RS29760 9489..9734 - 246 WP_032440458.1 hypothetical protein -
IS499_RS29765 10379..11866 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T180665 WP_071177730.1 NZ_CP064239:c8041-7727 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T180665 NZ_CP085633:c24146-23760 [Pectobacterium brasiliense]
ATGGAGGTTTACAGATTGGCATGGGAAATAGTCACACGGGCACTATTCGATACGTGGTTTGATGAGCAAACTGAAACGGT
ACAGGAAGAGATTTTGGCACACCTCGCTATACTCGAAGAGGATGGCCCACAGCTAGGGCGACCACAGGTTGATCAGATTA
AAGGCTCAAAATACAAAAATATGAAGGAGCTTCGAGTTCAGGTTGGCGGCCACCCATTCCGAACATTCTTCGCGTTTGAC
CGGACACGTAAAGCGATTGTTTTATGTGCGGGAGATAAGAAAGGCGAAGATGAAAAGTTGTTCTACGAACGTATGATTAA
GATCGCAGACGCTGAGTTTGCATCGCATCTGACATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT180665 WP_000093040.1 NZ_CP064239:c8307-8029 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT180665 NZ_CP085633:c23773-23474 [Pectobacterium brasiliense]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCTCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAATTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCGTTAGCACTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAAAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACTGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References