Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 138596..139506 Replicon plasmid pJX5-1
Accession NZ_CP064233
Organism Klebsiella pneumoniae strain JX-CR-hvKP-5

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag IS503_RS26615 Protein ID WP_004026354.1
Coordinates 139036..139506 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag IS503_RS26610 Protein ID WP_004026357.1
Coordinates 138596..139039 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS503_RS26580 133614..134135 + 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -
IS503_RS26585 134132..135085 + 954 Protein_146 fec operon regulator FecR -
IS503_RS26590 135172..137298 + 2127 WP_004213640.1 TonB-dependent receptor family protein -
IS503_RS26595 137373..137528 + 156 WP_004213642.1 hypothetical protein -
IS503_RS26600 137673..137894 + 222 WP_004213643.1 DUF2188 domain-containing protein -
IS503_RS26605 137992..138495 + 504 Protein_150 DUF4113 domain-containing protein -
IS503_RS26610 138596..139039 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
IS503_RS26615 139036..139506 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
IS503_RS26620 139655..140352 + 698 Protein_153 IS1 family transposase -
IS503_RS26625 141738..142687 - 950 Protein_154 DUF1173 family protein -
IS503_RS26630 142865..143359 + 495 WP_004212794.1 thermonuclease family protein -
IS503_RS26635 143696..144094 + 399 WP_004212796.1 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB 1..228973 228973
- flank IS/Tn - - 139849..140352 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T180630 WP_004026354.1 NZ_CP064233:139036-139506 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T180630 NZ_CP085619:c4350109-4349936 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT180630 WP_004026357.1 NZ_CP064233:138596-139039 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT180630 NZ_CP085619:c4350433-4350137 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References