Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4856287..4856803 Replicon chromosome
Accession NZ_CP064232
Organism Klebsiella pneumoniae strain JX-CR-hvKP-5

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IS503_RS23240 Protein ID WP_004178374.1
Coordinates 4856287..4856571 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IS503_RS23245 Protein ID WP_002886901.1
Coordinates 4856561..4856803 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS503_RS23215 4851683..4851991 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
IS503_RS23220 4852076..4852249 + 174 WP_041169004.1 hypothetical protein -
IS503_RS23225 4852252..4852995 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IS503_RS23230 4853352..4855490 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IS503_RS23235 4855819..4856283 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IS503_RS23240 4856287..4856571 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS503_RS23245 4856561..4856803 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IS503_RS23250 4856881..4858791 - 1911 WP_012737231.1 BglG family transcription antiterminator -
IS503_RS23255 4858814..4859968 - 1155 WP_012737230.1 lactonase family protein -
IS503_RS23260 4860035..4860775 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T180627 WP_004178374.1 NZ_CP064232:c4856571-4856287 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180627 NZ_CP085619:c3939287-3938973 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180627 WP_002886901.1 NZ_CP064232:c4856803-4856561 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180627 NZ_CP085619:c3939523-3939290 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References