Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 13284..14194 Replicon plasmid pJX6-1
Accession NZ_CP064230
Organism Klebsiella pneumoniae strain JX-CR-hvKP-6

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag IS501_RS25920 Protein ID WP_004026354.1
Coordinates 13284..13754 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag IS501_RS25925 Protein ID WP_004026357.1
Coordinates 13751..14194 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS501_RS25900 8696..9094 - 399 WP_004212796.1 H-NS histone family protein -
IS501_RS25905 9431..9925 - 495 WP_004212794.1 thermonuclease family protein -
IS501_RS25910 10103..11052 + 950 Protein_12 DUF1173 family protein -
IS501_RS25915 12438..13135 - 698 Protein_13 IS1 family transposase -
IS501_RS25920 13284..13754 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
IS501_RS25925 13751..14194 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
IS501_RS25930 14295..14798 - 504 Protein_16 DUF4113 domain-containing protein -
IS501_RS25935 14896..15117 - 222 WP_004213643.1 DUF2188 domain-containing protein -
IS501_RS25940 15262..15417 - 156 WP_004213642.1 hypothetical protein -
IS501_RS25945 15492..17618 - 2127 WP_004213640.1 TonB-dependent receptor family protein -
IS501_RS25950 17705..18658 - 954 Protein_20 fec operon regulator FecR -
IS501_RS25955 18655..19176 - 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..228974 228974
- flank IS/Tn - - 12438..12941 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T180608 WP_004026354.1 NZ_CP064230:c13754-13284 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T180608 NZ_CP085537:11168-11494 [Aeromonas salmonicida subsp. salmonicida]
ATGATGCGCGGCGACCTTGTGACCATCGCCATGCAGGGCGACTTTGGCAAGCCACGGCCTGCGCTTGTGGTTCAGGCCAA
CCAGTTCAGCGAGCACGGCAGCGTTACCGTGCTGCCTGTCACCAGCACACTTAATGCCGCGCCGTTGCTGCGCGTCACGG
TTCAGCCGAGCGCAGAGAACGGTTTGCAGAAGCCATCGCAGGTGATGGTCGACAAGGCGATGACGGTGCTGCGCAGCAAG
GTAGGGCCAGCTTTCGGGCGCATCGACGCGGACGCACTGCTTGAGGTTGAGCGTTGCTTGGCCGTGTTCTTGGGGATTGC
GAAATGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT180608 WP_004026357.1 NZ_CP064230:c14194-13751 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT180608 NZ_CP085537:10947-11171 [Aeromonas salmonicida subsp. salmonicida]
ATGGCAACAGCACACGTTAATCAGCGGGTTCAGAAGCATCGCGATGCATTACGCATGGCGGGGCTTCGTCCGGTTCAAAT
CTGGGTGCCGGATACGCGCCGCCCCGACTTCGCGGAGGAGTGCCGCCGCCAATGCCTGCTTGTGGCTCAGGCCGACAGCG
CCGACACCGCCATGCAGCAGTTCATGGATGAAGCCTTGGCAGACGTGGACGGCTGGACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References