Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4097659..4098278 Replicon chromosome
Accession NZ_CP064229
Organism Klebsiella pneumoniae strain JX-CR-hvKP-6

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IS501_RS19675 Protein ID WP_002892050.1
Coordinates 4098060..4098278 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IS501_RS19670 Protein ID WP_002892066.1
Coordinates 4097659..4098033 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS501_RS19660 4092811..4094004 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IS501_RS19665 4094027..4097173 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IS501_RS19670 4097659..4098033 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IS501_RS19675 4098060..4098278 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IS501_RS19680 4098437..4099003 + 567 WP_002892030.1 maltose O-acetyltransferase -
IS501_RS19685 4098975..4099115 - 141 WP_004147370.1 hypothetical protein -
IS501_RS19690 4099136..4099606 + 471 WP_002892026.1 YlaC family protein -
IS501_RS19695 4099581..4101032 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
IS501_RS19700 4101133..4101831 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
IS501_RS19705 4101828..4101968 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IS501_RS19710 4101968..4102231 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T180604 WP_002892050.1 NZ_CP064229:4098060-4098278 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T180604 NZ_CP085532:c3752736-3752344 [Mycobacterium tuberculosis variant bovis BCG]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT180604 WP_002892066.1 NZ_CP064229:4097659-4098033 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT180604 NZ_CP085532:c3753011-3752736 [Mycobacterium tuberculosis variant bovis BCG]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References