Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 61879..62438 Replicon plasmid pJX7-3
Accession NZ_CP064226
Organism Klebsiella pneumoniae strain JX-CR-hvKP-7

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag IS505_RS29205 Protein ID WP_000421257.1
Coordinates 61879..62154 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag IS505_RS29210 Protein ID WP_001178089.1
Coordinates 62154..62438 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS505_RS29170 57058..58449 - 1392 WP_000085084.1 SIR2 family protein -
IS505_RS29175 58526..59011 - 486 Protein_77 recombinase family protein -
IS505_RS29180 59075..59779 + 705 WP_001067845.1 IS6-like element IS26 family transposase -
IS505_RS29185 59866..60213 - 348 WP_000142451.1 hypothetical protein -
IS505_RS29190 60342..60677 + 336 WP_001080730.1 colicin 1A immunity protein -
IS505_RS29195 60699..61058 - 360 WP_085452786.1 colicin -
IS505_RS29200 61132..61829 + 698 Protein_82 IS1 family transposase -
IS505_RS29205 61879..62154 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS505_RS29210 62154..62438 - 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
IS505_RS29215 63082..64086 - 1005 WP_021546935.1 IS110-like element IS4321 family transposase -
IS505_RS29220 64276..64980 - 705 WP_001067845.1 IS6-like element IS26 family transposase -
IS505_RS29225 65044..65280 - 237 Protein_87 DUF3330 domain-containing protein -
IS505_RS29230 65483..66496 - 1014 WP_000845048.1 class 1 integron integrase IntI1 -
IS505_RS29235 66676..67230 + 555 WP_032488579.1 aminoglycoside N-acetyltransferase AAC(6')-Ib3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn cmlA1 / qacE / blaCTX-M-14 / blaTEM-1B - 51777..86462 34685
- inside Non-Mobilizable plasmid cmlA1 / qacE / blaCTX-M-14 / blaTEM-1B - 1..91913 91913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T180586 WP_000421257.1 NZ_CP064226:c62154-61879 [Klebsiella pneumoniae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T180586 NZ_CP085532:c2329398-2328964 [Mycobacterium tuberculosis variant bovis BCG]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT180586 WP_001178089.1 NZ_CP064226:c62438-62154 [Klebsiella pneumoniae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT180586 NZ_CP085532:c2329659-2329405 [Mycobacterium tuberculosis variant bovis BCG]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References