Detailed information of TA system TA180579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 74924..75834
• Replicon: plasmid pJX7-1
• Accession: NZ_CP064224
• Organism: Klebsiella pneumoniae strain JX-CR-hvKP-7

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A663AYG0
• Locus tag: IS505_RS27270
• Protein ID: WP_004026354.1
• Coordinates: 75364..75834 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6P1V3Q9
• Locus tag: IS505_RS27265
• Protein ID: WP_004026357.1
• Coordinates: 74924..75367 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IS505_RS27240	70433..71335	+	903	WP_004213613.1	DMT family transporter	-
IS505_RS27245	71478..71699	-	222	WP_004213615.1	hypothetical protein	-
IS505_RS27250	71761..73068	-	1308	Protein_85	FepA family TonB-dependent siderophore receptor	-
IS505_RS27255	73134..74114	+	981	WP_000019473.1	IS5-like element ISKpn26 family transposase	-
IS505_RS27260	74320..74823	+	504	Protein_87	DUF4113 domain-containing protein	-
IS505_RS27265	74924..75367	+	444	WP_004026357.1	DUF2384 domain-containing protein	Antitoxin
IS505_RS27270	75364..75834	+	471	WP_004026354.1	RES family NAD+ phosphorylase	Toxin
IS505_RS27275	75983..76680	+	698	Protein_90	IS1 family transposase	-
IS505_RS27280	78066..79015	-	950	Protein_91	DUF1173 family protein	-
IS505_RS27285	79193..79687	+	495	WP_004212794.1	thermonuclease family protein	-
IS505_RS27290	80024..80422	+	399	WP_004212796.1	H-NS histone family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN	1..219796	219796
	-	inside	IScluster/Tn	-	-	73134..81873	8739

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17515.79 Da
• Isoelectric Point: 4.6155

>T180579 WP_004026354.1 NZ_CP064224:75364-75834 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T180579 NZ_CP085532:c2179629-2179300 [Mycobacterium tuberculosis variant bovis BCG]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16480.80 Da
• Isoelectric Point: 10.2498

>AT180579 WP_004026357.1 NZ_CP064224:74924-75367 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT180579 NZ_CP085532:c2180003-2179626 [Mycobacterium tuberculosis variant bovis BCG]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A663AYG0

Antitoxin

• AlphaFold DB: A0A6P1V3Q9