Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4888804..4889320 Replicon chromosome
Accession NZ_CP064223
Organism Klebsiella pneumoniae strain JX-CR-hvKP-7

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IS505_RS24150 Protein ID WP_002886902.1
Coordinates 4888804..4889088 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IS505_RS24155 Protein ID WP_002886901.1
Coordinates 4889078..4889320 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS505_RS24125 4884288..4884596 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IS505_RS24130 4884681..4884854 + 174 WP_002886906.1 hypothetical protein -
IS505_RS24135 4884857..4885600 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IS505_RS24140 4885957..4888095 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IS505_RS24145 4888336..4888800 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IS505_RS24150 4888804..4889088 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS505_RS24155 4889078..4889320 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IS505_RS24160 4889398..4891308 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IS505_RS24165 4891331..4892485 - 1155 WP_002886900.1 lactonase family protein -
IS505_RS24170 4892551..4893291 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T180575 WP_002886902.1 NZ_CP064223:c4889088-4888804 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180575 NZ_CP085532:1685040-1685357 [Mycobacterium tuberculosis variant bovis BCG]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180575 WP_002886901.1 NZ_CP064223:c4889320-4889078 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180575 NZ_CP085532:1684741-1685043 [Mycobacterium tuberculosis variant bovis BCG]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTTGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References