Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4875879..4876395 Replicon chromosome
Accession NZ_CP064217
Organism Klebsiella pneumoniae strain JX-CR-hvKP-8

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IS494_RS24030 Protein ID WP_002886902.1
Coordinates 4875879..4876163 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IS494_RS24035 Protein ID WP_002886901.1
Coordinates 4876153..4876395 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS494_RS24005 4871363..4871671 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IS494_RS24010 4871756..4871929 + 174 WP_002886906.1 hypothetical protein -
IS494_RS24015 4871932..4872675 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IS494_RS24020 4873032..4875170 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IS494_RS24025 4875411..4875875 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IS494_RS24030 4875879..4876163 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS494_RS24035 4876153..4876395 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IS494_RS24040 4876473..4878383 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IS494_RS24045 4878406..4879560 - 1155 WP_002886900.1 lactonase family protein -
IS494_RS24050 4879626..4880366 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T180541 WP_002886902.1 NZ_CP064217:c4876163-4875879 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180541 NZ_CP085527:c847967-847794 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180541 WP_002886901.1 NZ_CP064217:c4876395-4876153 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180541 NZ_CP085527:c848293-847964 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References