Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4802447..4802963 Replicon chromosome
Accession NZ_CP064211
Organism Klebsiella pneumoniae strain JX-CR-hvKP-9

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IS495_RS23630 Protein ID WP_002886902.1
Coordinates 4802447..4802731 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IS495_RS23635 Protein ID WP_002886901.1
Coordinates 4802721..4802963 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS495_RS23605 4797931..4798239 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IS495_RS23610 4798324..4798497 + 174 WP_002886906.1 hypothetical protein -
IS495_RS23615 4798500..4799243 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IS495_RS23620 4799600..4801738 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IS495_RS23625 4801979..4802443 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IS495_RS23630 4802447..4802731 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS495_RS23635 4802721..4802963 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IS495_RS23640 4803041..4804951 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IS495_RS23645 4804974..4806128 - 1155 WP_002886900.1 lactonase family protein -
IS495_RS23650 4806194..4806934 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T180509 WP_002886902.1 NZ_CP064211:c4802731-4802447 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180509 NZ_CP085488:3639788-3640066 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180509 WP_002886901.1 NZ_CP064211:c4802963-4802721 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180509 NZ_CP085488:3639525-3639785 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References