Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4793055..4793571 Replicon chromosome
Accession NZ_CP064208
Organism Klebsiella pneumoniae strain JX-CR-hvKP-11

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IS500_RS22855 Protein ID WP_004178374.1
Coordinates 4793055..4793339 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IS500_RS22860 Protein ID WP_002886901.1
Coordinates 4793329..4793571 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS500_RS22830 4788451..4788759 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
IS500_RS22835 4788844..4789017 + 174 WP_041169004.1 hypothetical protein -
IS500_RS22840 4789020..4789763 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IS500_RS22845 4790120..4792258 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IS500_RS22850 4792587..4793051 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IS500_RS22855 4793055..4793339 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS500_RS22860 4793329..4793571 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IS500_RS22865 4793649..4795559 - 1911 WP_012737231.1 BglG family transcription antiterminator -
IS500_RS22870 4795582..4796736 - 1155 WP_012737230.1 lactonase family protein -
IS500_RS22875 4796803..4797543 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T180489 WP_004178374.1 NZ_CP064208:c4793339-4793055 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180489 NZ_CP085481:c755883-755479 [Proteus sp. NMG38-2]
ATGATTAAATATCTGCTAGATACGAATATTGTTATATTTACAATTAAACGTAGACCTGAATTTCTGTTACCAAAATTTAA
TCAGTATGTTGAACAGCTAGCTATTTCAACAATAACACTTGCTGAACTACTATATGGTGCTGAAAAAAGCTCAAATTCAG
CAAAAAATTTAGCTACTGTTAATGATTTCGTTTCTAGACTAAATGTTTTACCTTATGACGAACTTGCAGCCTTTCACTAT
GGTGATATAAGAGCAACACTCGAAAAGCAAGGTAAACGCATTGGTGATAATGACTTGCATATAGCAGCACATGCCAGAAG
CAAAGGATTAATCGTCGTTACAAATAATACCAAAGAGTTTGAGAGAGTTGATGGTTTAAGGATTGAAGATTGGACTCATC
ATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180489 WP_002886901.1 NZ_CP064208:c4793571-4793329 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180489 NZ_CP085481:c756118-755876 [Proteus sp. NMG38-2]
ATGATCCAGCATGGCAAAGTATTTATGAGCAATAGAACACAAAATGTTCGTTTACCTGCTGATACTCGTTTTCCTGATGA
TGTAAAAGACGTTGTGGTTCGTGTAAAAGGAAAAGAGAGAATTATCACACCGATACAGAATGCATGGGATAGCTTTTTCT
TATCTGAAAAGTCTGTAACAGATGATTTTTTATCTGAAAGACCAGATCAAGTCACAAGCGAAAGAGAATCCTTTGATGAT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References