Detailed information of TA system TA180455

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3936191..3936844
• Replicon: plasmid unnamed1
• Accession: NZ_CP064203
• Organism: Acinetobacter baumannii strain X4-300

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IS510_RS19050
• Protein ID: WP_000607077.1
• Coordinates: 3936455..3936844 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: IS510_RS19045
• Protein ID: WP_001288210.1
• Coordinates: 3936191..3936448 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IS510_RS19025	3931707..3932714	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
IS510_RS19030	3932733..3933110	+	378	WP_001216380.1	50S ribosomal protein L17	-
IS510_RS19035	3933292..3934782	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
IS510_RS19040	3934831..3936003	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
IS510_RS19045	3936191..3936448	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
IS510_RS19050	3936455..3936844	+	390	WP_000607077.1	membrane protein	Toxin
IS510_RS19055	3937614..3938699	+	1086	WP_000049106.1	hypothetical protein	-
IS510_RS19060	3938777..3939343	+	567	WP_000651538.1	rhombosortase	-
IS510_RS19065	3939531..3941726	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaADC-25 / blaOXA-66 / blaTEM-1D / tet(X6) / tet(Y) / aph(3')-Ia / sul2 / floR / aph(6)-Id / aph(3'')-Ib	plcD / ompA / pilG / pilH / htpB / bauF / basA / basB / bauD / bauC / bauE / bauB / bauA / basC / basD / entE / basF / basG / barA / barB / basH / basI / basJ / adeH / adeG / adeF / csuA/B / csuA / csuB / csuC / csuD / csuE / pgaB / pgaC / pgaD / plc / katA / pilT / pilU / tufA / bfmS / bfmR / tufA / abaR / abaI / wbtL / tviB / plc / plc	1..3973223	3973223

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T180455 WP_000607077.1 NZ_CP064203:3936455-3936844 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T180455 NZ_CP085398:304003-304353 [Rossellomorea marisflavi]
TTGATTGTAAAGCGTGGTGACGTATATTTTGCAGACCTTTCTCCTGTTGTTGGGTCGGAACAAGGAGGCGTCCGGCCGGT
CCTTGTCATTCAAAACGATATAGGGAACAGGTTCAGTCCCACTGTTATTGTCGCTGCTATCACTGCTCAGATCCAAAAAG
CGAAGTTGCCTACCCATGTCGAAATCGATTCCAAACGGTACGGCTTTGAACGTGATTCCGTAATCTTGCTCGAACAGATC
AGGACCATCGATAAACAGCGTCTTACCGATAAGATCACACACCTGGACGACGAAATGATGGAGAAAGTCGATGACGCCCT
CCAGATCAGTGTGGGTCTCATACAATTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT180455 WP_001288210.1 NZ_CP064203:3936191-3936448 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT180455 NZ_CP085398:303717-303998 [Rossellomorea marisflavi]
GTGTCTGAATCCAGCGCAACAACGGAAATTTTGATTCGTCTTCCGCAACAGCTCGTCACAGAACTGGACGGCTTTGCAGA
TCAGGAAAATGTGAATCGCAATGAGTTTATTTATCGTGCTACTAAAATGTATTTAAGAGAGCGTAAGAAACGACATCTGC
GTGAATCCATGAGACGAGGCTATATGGAAATGGCTAAGATCAATCTCGCCATCGCTTCGGAAGCAATCCAGGCAGAATAT
GAGGCAGAACATACAGTCGAACGCTTAGTAAGCGGAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7