Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 709154..709805 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP064203 | ||
| Organism | Acinetobacter baumannii strain X4-300 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A5Q0RPK1 |
| Locus tag | IS510_RS03345 | Protein ID | WP_000838147.1 |
| Coordinates | 709154..709336 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | L9LVK3 |
| Locus tag | IS510_RS03350 | Protein ID | WP_002053018.1 |
| Coordinates | 709401..709805 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IS510_RS03300 | 704487..704855 | + | 369 | WP_025467978.1 | hypothetical protein | - |
| IS510_RS03305 | 704911..705330 | + | 420 | WP_002053092.1 | hypothetical protein | - |
| IS510_RS03310 | 705330..705782 | + | 453 | WP_002053117.1 | hypothetical protein | - |
| IS510_RS03315 | 705846..706259 | + | 414 | WP_031965420.1 | hypothetical protein | - |
| IS510_RS03320 | 706225..706593 | + | 369 | WP_001983390.1 | hypothetical protein | - |
| IS510_RS03325 | 706595..706993 | + | 399 | WP_030423713.1 | phage tail terminator-like protein | - |
| IS510_RS03330 | 706995..707207 | + | 213 | WP_030423712.1 | hypothetical protein | - |
| IS510_RS03335 | 707315..708244 | + | 930 | WP_049594449.1 | phage tail tube protein | - |
| IS510_RS03340 | 708289..708822 | + | 534 | WP_057691629.1 | hypothetical protein | - |
| IS510_RS03345 | 709154..709336 | + | 183 | WP_000838147.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| IS510_RS03350 | 709401..709805 | + | 405 | WP_002053018.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| IS510_RS03355 | 709901..710419 | + | 519 | WP_005070358.1 | DUF4468 domain-containing protein | - |
| IS510_RS03360 | 710516..714487 | + | 3972 | WP_279446913.1 | tape measure protein | - |
| IS510_RS03365 | 714527..714670 | + | 144 | WP_164523119.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaADC-25 / blaOXA-66 / blaTEM-1D / tet(X6) / tet(Y) / aph(3')-Ia / sul2 / floR / aph(6)-Id / aph(3'')-Ib | plcD / ompA / pilG / pilH / htpB / bauF / basA / basB / bauD / bauC / bauE / bauB / bauA / basC / basD / entE / basF / basG / barA / barB / basH / basI / basJ / adeH / adeG / adeF / csuA/B / csuA / csuB / csuC / csuD / csuE / pgaB / pgaC / pgaD / plc / katA / pilT / pilU / tufA / bfmS / bfmR / tufA / abaR / abaI / wbtL / tviB / plc / plc | 1..3973223 | 3973223 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6682.88 Da Isoelectric Point: 10.6602
>T180454 WP_000838147.1 NZ_CP064203:709154-709336 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK
Download Length: 183 bp
>T180454 NZ_CP085397:278047-278397 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTTGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACGCATGTTGAGATTAATGCAAAAAAATACGGATTCGAGCGGGATTCCGTCATTTTATTAGAACAGATC
CGGACAATTGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATTAGTCTAGGCCTCATTGAGTTTTAA
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTTGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACGCATGTTGAGATTAATGCAAAAAAATACGGATTCGAGCGGGATTCCGTCATTTTATTAGAACAGATC
CGGACAATTGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATTAGTCTAGGCCTCATTGAGTTTTAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14660.69 Da Isoelectric Point: 4.4289
>AT180454 WP_002053018.1 NZ_CP064203:709401-709805 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT180454 NZ_CP085397:277758-278039 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATAGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATAGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q0RPK1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q0RVR6 |