180453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 6..594 Replicon chromosome
Accession NZ_CP064202
Organism Acinetobacter baumannii strain X4-300

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag IS510_RS00005 Protein ID WP_000438826.1
Coordinates 6..293 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag IS510_RS00010 Protein ID WP_001983304.1
Coordinates 280..594 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS510_RS00005 6..293 + 288 WP_000438826.1 BrnT family toxin Toxin
IS510_RS00010 280..594 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
IS510_RS00015 722..3133 + 2412 WP_279446691.1 TonB-dependent receptor ZnuD2 -
IS510_RS00020 3438..3899 + 462 WP_279446692.1 DIP1984 family protein -
IS510_RS00025 4222..4395 - 174 WP_001282484.1 hypothetical protein -
IS510_RS00030 4395..4766 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T180453 WP_000438826.1 NZ_CP064202:6-293 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T180453 NZ_CP085395:293298-293648 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTCGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAACGGGATTCCGTCATTTTATTAGAACAGATC
CGGACTATCGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGCCTCATTGAGTTTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT180453 WP_001983304.1 NZ_CP064202:280-594 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT180453 NZ_CP085395:293009-293290 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGACGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References