Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 6..594 Replicon chromosome
Accession NZ_CP064202
Organism Acinetobacter baumannii strain X4-300

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag IS510_RS00005 Protein ID WP_000438826.1
Coordinates 6..293 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag IS510_RS00010 Protein ID WP_001983304.1
Coordinates 280..594 (+) Length 105 a.a.

Genomic Context

IS510_RS00005IS510_RS00010IS510_RS00015IS510_RS00020IS510_RS00025IS510_RS00030
Location: 6..293 (288 bp)
Type: Toxin
Protein ID: WP_000438826.1
Location: 280..594 (315 bp)
Type: Antitoxin
Protein ID: WP_001983304.1
Location: 722..3133 (2412 bp)
Type: Others
Protein ID: WP_279446691.1
Location: 3438..3899 (462 bp)
Type: Others
Protein ID: WP_279446692.1
Location: 4222..4395 (174 bp)
Type: Others
Protein ID: WP_001282484.1
Location: 4395..4766 (372 bp)
Type: Others
Protein ID: WP_000504218.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IS510_RS000056..293+288WP_000438826.1BrnT family toxinToxin
IS510_RS00010280..594+315WP_001983304.1BrnA antitoxin family proteinAntitoxin
IS510_RS00015722..3133+2412WP_279446691.1TonB-dependent receptor ZnuD2-
IS510_RS000203438..3899+462WP_279446692.1DIP1984 family protein-
IS510_RS000254222..4395-174WP_001282484.1hypothetical protein-
IS510_RS000304395..4766-372WP_000504218.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T180453 WP_000438826.1 NZ_CP064202:6-293 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T180453 NZ_CP085395:293298-293648 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTCGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAACGGGATTCCGTCATTTTATTAGAACAGATC
CGGACTATCGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGCCTCATTGAGTTTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT180453 WP_001983304.1 NZ_CP064202:280-594 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT180453 NZ_CP085395:293009-293290 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGACGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3G6Z3M6

Antitoxin

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Source
ID
Structure
AlphaFold DBN9M5I3

References