Detailed information of TA system TA180452

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3482329..3482982
• Replicon: chromosome
• Accession: NZ_CP064194
• Organism: Acinetobacter baumannii strain X4-65

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IS507_RS16835
• Protein ID: WP_000607077.1
• Coordinates: 3482329..3482718 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: IS507_RS16840
• Protein ID: WP_001288210.1
• Coordinates: 3482725..3482982 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IS507_RS16820	3477447..3479642	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
IS507_RS16825	3479830..3480396	-	567	WP_000651538.1	rhombosortase	-
IS507_RS16830	3480474..3481559	-	1086	WP_000049106.1	hypothetical protein	-
IS507_RS16835	3482329..3482718	-	390	WP_000607077.1	membrane protein	Toxin
IS507_RS16840	3482725..3482982	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
IS507_RS16845	3483170..3484342	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
IS507_RS16850	3484391..3485881	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
IS507_RS16855	3486063..3486440	-	378	WP_001216380.1	50S ribosomal protein L17	-
IS507_RS16860	3486459..3487466	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T180452 WP_000607077.1 NZ_CP064194:c3482718-3482329 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T180452 NZ_CP085394:2574977-2575741 [Bacillus sp. CMF12]
TTGCTCCTTTTCTTTAAGATTGTGGTTTGGATGATTGTCGCTTGTCTCGGGTTTTATGTTTTTTCTGTGTGGAGATGGGA
AAAGAAAGTTAAGGAAAGAATGTTTGCGATCCGGAAGACCTGGTATATCATCTATGTACTGGGGGCGGTTATTTATTGGA
CCAAAGTGCCGGAGTCCATTTTCACAGACTGGCTGAATTACCTGATTGTTGCGATTATTTTTGCGCTTGTTGATGCATTT
ATTTTCCTGGGCTCTTACCTGAAAAGAGTCGGCAATAATGAACTGGCAACGGATACGATGGAATTGCTCGAAGAAAATAA
CGACCTTTTGAACTCACAAATGAATAAACTGAAATCCTTTCAGTATTTGTTGAAAAATGAACCGATCGACGTTTATTATG
GAGATATGGAAGCCTATATTGCAGGCATTGAAAAACTTTTGGCAGACTATGCAGAAAAAGTGGATATGAAAGCTTCTTTA
TGCAAATACACGACACAGGAAGATAAAGATTATTTGCTTGAGCACTATCCTGATAAAGCGTTAATTCACAGCCGGCTGGA
CCGCAAGGAAGTGTATTATGATGCCGATGAAAAATTGGCATTAATTCCTTTTTCCATCCTTGAAGACTATTATGTTATTA
AATTGACCTCCGATGATTTTGTCACCGAATTCGACTACTTGTTATTCACTTCACTCATATCAATATACGACCTAATGCTC
CCTGCTGAACAGGAGGACGAAGACCATGAAGGAACCAGCGGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT180452 WP_001288210.1 NZ_CP064194:c3482982-3482725 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT180452 NZ_CP085394:2575722-2575895 [Bacillus sp. CMF12]
ATGAAGGAACCAGCGGATAAAGAAAAGCACAAATTGAGTACAAAGAACAACATGAAAATCATGAAAAAGAAGTCGAGGAT
CAATCTTCCTGACTTTGAAGTCAGCCCGCATACCGAACGGATTATAAAAGAGAATAAAAGATTGATAAGCGTTTATACAA
AAAGCAAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7