Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2736143..2736794 Replicon chromosome
Accession NZ_CP064194
Organism Acinetobacter baumannii strain X4-65

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag IS507_RS13365 Protein ID WP_000838147.1
Coordinates 2736612..2736794 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag IS507_RS13360 Protein ID WP_002053018.1
Coordinates 2736143..2736547 (-) Length 135 a.a.

Genomic Context

IS507_RS13345IS507_RS13350IS507_RS13355IS507_RS13360IS507_RS13365IS507_RS13370IS507_RS13375IS507_RS13380IS507_RS13385IS507_RS13390IS507_RS13395IS507_RS13400IS507_RS13405IS507_RS13410
Location: 2731278..2731421 (144 bp)
Type: Others
Protein ID: WP_164523119.1
Location: 2731461..2735432 (3972 bp)
Type: Others
Protein ID: WP_279446913.1
Location: 2735529..2736047 (519 bp)
Type: Others
Protein ID: WP_005070358.1
Location: 2736143..2736547 (405 bp)
Type: Antitoxin
Protein ID: WP_002053018.1
Location: 2736612..2736794 (183 bp)
Type: Toxin
Protein ID: WP_000838147.1
Location: 2737126..2737659 (534 bp)
Type: Others
Protein ID: WP_057691629.1
Location: 2737704..2738633 (930 bp)
Type: Others
Protein ID: WP_049594449.1
Location: 2738741..2738953 (213 bp)
Type: Others
Protein ID: WP_030423712.1
Location: 2738955..2739353 (399 bp)
Type: Others
Protein ID: WP_030423713.1
Location: 2739355..2739723 (369 bp)
Type: Others
Protein ID: WP_001983390.1
Location: 2739689..2740102 (414 bp)
Type: Others
Protein ID: WP_031965420.1
Location: 2740166..2740618 (453 bp)
Type: Others
Protein ID: WP_002053117.1
Location: 2740618..2741037 (420 bp)
Type: Others
Protein ID: WP_002053092.1
Location: 2741093..2741461 (369 bp)
Type: Others
Protein ID: WP_025467978.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IS507_RS133452731278..2731421-144WP_164523119.1hypothetical protein-
IS507_RS133502731461..2735432-3972WP_279446913.1tape measure protein-
IS507_RS133552735529..2736047-519WP_005070358.1DUF4468 domain-containing protein-
IS507_RS133602736143..2736547-405WP_002053018.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
IS507_RS133652736612..2736794-183WP_000838147.1type II toxin-antitoxin system HicA family toxinToxin
IS507_RS133702737126..2737659-534WP_057691629.1hypothetical protein-
IS507_RS133752737704..2738633-930WP_049594449.1phage tail tube protein-
IS507_RS133802738741..2738953-213WP_030423712.1hypothetical protein-
IS507_RS133852738955..2739353-399WP_030423713.1phage tail terminator-like protein-
IS507_RS133902739355..2739723-369WP_001983390.1hypothetical protein-
IS507_RS133952739689..2740102-414WP_031965420.1hypothetical protein-
IS507_RS134002740166..2740618-453WP_002053117.1hypothetical protein-
IS507_RS134052740618..2741037-420WP_002053092.1hypothetical protein-
IS507_RS134102741093..2741461-369WP_025467978.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2719262..276725047988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T180451 WP_000838147.1 NZ_CP064194:c2736794-2736612 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T180451 NZ_CP085394:254747-255097 [Bacillus sp. CMF12]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT180451 WP_002053018.1 NZ_CP064194:c2736547-2736143 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT180451 NZ_CP085394:254461-254742 [Bacillus sp. CMF12]
GTGTCTGAGTCCAGCACAACAACAGAGATAATGGTGAAATTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAT
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5Q0RPK1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5Q0RVR6

References