Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2736143..2736794 Replicon chromosome
Accession NZ_CP064194
Organism Acinetobacter baumannii strain X4-65

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag IS507_RS13365 Protein ID WP_000838147.1
Coordinates 2736612..2736794 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag IS507_RS13360 Protein ID WP_002053018.1
Coordinates 2736143..2736547 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS507_RS13345 2731278..2731421 - 144 WP_164523119.1 hypothetical protein -
IS507_RS13350 2731461..2735432 - 3972 WP_279446913.1 tape measure protein -
IS507_RS13355 2735529..2736047 - 519 WP_005070358.1 DUF4468 domain-containing protein -
IS507_RS13360 2736143..2736547 - 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IS507_RS13365 2736612..2736794 - 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
IS507_RS13370 2737126..2737659 - 534 WP_057691629.1 hypothetical protein -
IS507_RS13375 2737704..2738633 - 930 WP_049594449.1 phage tail tube protein -
IS507_RS13380 2738741..2738953 - 213 WP_030423712.1 hypothetical protein -
IS507_RS13385 2738955..2739353 - 399 WP_030423713.1 phage tail terminator-like protein -
IS507_RS13390 2739355..2739723 - 369 WP_001983390.1 hypothetical protein -
IS507_RS13395 2739689..2740102 - 414 WP_031965420.1 hypothetical protein -
IS507_RS13400 2740166..2740618 - 453 WP_002053117.1 hypothetical protein -
IS507_RS13405 2740618..2741037 - 420 WP_002053092.1 hypothetical protein -
IS507_RS13410 2741093..2741461 - 369 WP_025467978.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2719262..2767250 47988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T180451 WP_000838147.1 NZ_CP064194:c2736794-2736612 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T180451 NZ_CP085394:254747-255097 [Bacillus sp. CMF12]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT180451 WP_002053018.1 NZ_CP064194:c2736547-2736143 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT180451 NZ_CP085394:254461-254742 [Bacillus sp. CMF12]
GTGTCTGAGTCCAGCACAACAACAGAGATAATGGTGAAATTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAT
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References