Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 945187..945754 Replicon chromosome
Accession NZ_CP064192
Organism Saccharothrix sp. 6-C

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IOD16_RS04450 Protein ID WP_123743528.1
Coordinates 945404..945754 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IOD16_RS04445 Protein ID WP_123743529.1
Coordinates 945187..945417 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD16_RS04415 940396..940626 - 231 WP_123743534.1 hypothetical protein -
IOD16_RS04425 940956..941801 + 846 WP_123743533.1 DUF2236 domain-containing protein -
IOD16_RS04435 942640..943701 + 1062 WP_201438979.1 sigma-70 family RNA polymerase sigma factor -
IOD16_RS04440 943758..945164 + 1407 WP_201441195.1 MFS transporter -
IOD16_RS04445 945187..945417 + 231 WP_123743529.1 ribbon-helix-helix domain-containing protein Antitoxin
IOD16_RS04450 945404..945754 + 351 WP_123743528.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IOD16_RS04455 945806..946000 - 195 WP_123743527.1 ferredoxin -
IOD16_RS04460 945997..947196 - 1200 WP_201438980.1 cytochrome P450 -
IOD16_RS04465 947383..948255 + 873 WP_201441196.1 ABC transporter ATP-binding protein -
IOD16_RS04470 948252..949103 + 852 WP_123743525.1 ABC transporter permease -
IOD16_RS04475 949100..949339 + 240 WP_123743524.1 helix-turn-helix transcriptional regulator -
IOD16_RS04480 949378..950532 - 1155 WP_201438981.1 glycosyl transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12238.12 Da        Isoelectric Point: 10.7059

>T180450 WP_123743528.1 NZ_CP064192:945404-945754 [Saccharothrix sp. 6-C]
MRRGDIYWVDLEPAQGAEANKIRPAVVVSNDAANRAAGRGGGRGVVTVVPITSNTAKVYPFQVLLPAKDCGLGADSKAQA
EQVRTVTAARLRARIGGLPPAVLKQLDEALRVHLSL

Download         Length: 351 bp

>T180450 NZ_CP085393:c61847-61443 [Cytobacillus oceanisediminis]
ATGAAAAGTGATGTAATTTTAAATAAAATAAATATAATTGAACGCTGTATTAAACGAATTCACGAGGAATACGACCAGAA
TCCTAAAAATCTAGAGAATTATACAAAGCAAGATTCAATTATTTTAAATCTGCAGCGGGCTTGTGAGGCAAGTATTGACT
TGGCCATGCACATAGTAGCCGTAAAAAAACTGGGACTCCCACAACAAAGCCGGGATGCATTTACCTTATTGGAAGCTGAG
GGTATTATTCCCTCCTCTCTTTCAGATAAGATGAAAGCTATGGTTGGATTTCGTAATATTGCAGTTCATGATTACCAAGA
GATTAATTTAGTGATCCTTCAAAAGATACTTGATAATCATTTAGTGGATTTCTTTGAATATACAAAAACCATTTTAATGC
ACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8490.35 Da        Isoelectric Point: 4.2080

>AT180450 WP_123743529.1 NZ_CP064192:945187-945417 [Saccharothrix sp. 6-C]
MKISVSLPEEDVEFVDRYLRQHRSASRSSVIHQAITLLREAGLENAYASAWEEWEAGGDADMWDVTAPDGVLDAAR

Download         Length: 231 bp

>AT180450 NZ_CP085393:c62244-61837 [Cytobacillus oceanisediminis]
TTGAATCCACACCTTGAAGAAACCATTATAGATGTACTTCGTGAAAAATTATCCCCCGATTGGATAGTTATGTTTGGTTC
AACCGTTAGTGGAAATACCCATAAAGAAAGTGACATTGATATTGCATATTTGAGTGACACAATTAAAGCAGATAAATATC
AAATATTTATGATTGCTCAGGAATTAGCAGCAAAACTCAACAAAGATGTGGACCTCATTGATTTAAATCAGGCCAGTACA
GTATTTCAAGCCCAAATAGTTCAATCCGGAACAACTATTTATTGTACCAATGAGCGAAAAAAAGCTGAATTTGAAGTTAA
AGTATTAAAAATGTATACGAAGCTAAATGAGGAGCGATCAGAGATATTAAAAAAAATTGACGAAAGCGGGACAATATATG
AAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References